Jul 14, 2010 4:49 AM GMT
I read something in the newspaper about an HIV antibody that "cures" something like 90% of cases. This wasn't the national enquirer this was the Arizona Republic. Why haven't I heard anything about this?
dancerjack saidcitation please
Cross-reactive neutralizing antibodies (NAbs) are found in the sera of many HIV-1-infected subjects, but the virologic basis of their neutralization remains poorly understood. We used knowledge of HIV-1 envelope (Env) structure to develop antigenically resurfaced glycoproteins specific for the structurally conserved site of CD4 receptor binding. These probes were used to identify sera with NAbs to the CD4-binding site (CD4bs) and to isolate individual B cells from such an HIV-1-infected donor. By expressing immunoglobulin genes from individual cells, we identified three monoclonal antibodies, including a pair of somatic variants that neutralized over 90% of circulating HIV-1 isolates. Exceptionally broad HIV-1 neutralization can be achieved with individual antibodies targeted to the functionally conserved CD4bs of gp120, an important insight for future HIV-1 vaccine design.
Science. 2010 Jul 8. [Epub ahead of print]
Remember HIV modifies quickly. It changes form to slip cells. Many times these sites on CD4-receptor binding sites are hidden in protein folds and not easily accessible to the antibody. This is still in beginning phases. It has only been tested in petri dishes only. It will be many more months or even years before the antibodies are understood enough to think about producing a vaccine. Then many years before an HIV vaccine is actually developed through all the hassles of pharma companies and patents and funding. .
Remember: This is NOT a cure. It is a great step towards it. When the develop the vaccine, the virus may again change forms so that the antibodies are rendered ineffective. There is no reason to have random unprotective sex. Even if there is an AIDS virus, there are always STDs.