Feb 14, 2008 8:00 PM GMT
"Laboratory studies have reported several potential mechanisms for selenium's beneficial effects in prostate cancer, including decrease in androgen receptors and PSA production, antioxidant effects, angiogenesis inhibition, or apoptosis.It is not known if selenium is helpful in men who already have been diagnosed with prostate cancer to prevent progression or recurrence of disease. It does appear that selenium may not be beneficial in those with elevated PSA levels, or with normal/high selenium levels. It remains unclear whether men at risk (or all men) should have their serum selenium values measured; results of the SELECT study may provide additional guidance. There is evidence that low selenium levels are associated with an increased risk of prostate cancer, and several mechanisms for the beneficial effects of selenium supplementation have been suggested.In the NPC trial, no benefits were seen in reducing the risk of colorectal or lung cancers. Although an overall reduction in cancer risk was observed, it is not clear which specific types of cancer besides prostate cancer prevention may benefit."