The two medications in truvada (emtricitabine and tenofovir) should be used with caution in individuals with renal disease or reduced renal function. Tenofovir has a reputation for causing kidney damage in a certain proportion of those who are on it in long-term use. In our practice, when a patient on truvada seems to have reduced renal function (as evidenced by elevated blood creatinine levels), we will get some bloodwork (a renal function panel) and a 24-hr urine collection that is assessed for both creatinine and protein. it has been my experience, after review of dozens of urinalyses, that our lab's (Labcorp) calculations of renal capacity (as glomerular filtration rate, GFR) are not that accurate as they don't correlate very well with the results of the 24-hr urinalyses.
I suggest that an appropriate assessment of kidney function would include a renal panel (blood) and a 24-hr collection (urine) for protein and creatinine. If your doctor finds you are spilling protein, glucose and phosphate in excessive amounts into your urine AND you have chronically elevated serum (blood) creatinine levels, you should consider stopping truvada. Discuss this in detail with your physician.