This fucking Effexor!!!!!!!!!

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    Feb 24, 2011 1:49 AM GMT
    My doc is weaning me off this slowly and I'm also on Wellbutrin (150mgs/day) as the replacement. I am down to 37.5mgs of effexor once every three days now. First day off is ok, second is a bit lite headed and dizzy, third is total fucking crash and burn, light headed dizzy, cunty, postal..I started weaning off 150mgs/day about 30 days ago....

    Can someone tell me it gets better??? jeez, this is killing me.....Keithicon_evil.gif
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    Feb 24, 2011 3:17 AM GMT
    I cannot tell you for sure.... however if the wellbutrin is working, that should make a big difference. Adding 37.5 mg every three days is not a high dose, so perhaps SOME of the symptoms could be psychosomatic. Of course it takes time for it to get all out of your system.

    Things should be better once you are off of the medication all together and once the Wellbutrin is fully in your system after a few weeks (3-6).

    Good luck... I hope you feel better.

    PS. Try to do some relaxation exercises when you feel crappy.... remember that its temporary and that it will be okay. Better times are ahead.
  • UnluckyTitan

    Posts: 106

    Feb 24, 2011 5:02 AM GMT
    Just out of curiosity, what dose were you on at the peak? I'm at 225 right now and want to talk to my doc about stopping all of my meds but from what I've heard read kicking effexor to the curb is a bitch.
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    Feb 24, 2011 7:09 AM GMT
    the max i was on was 225 and then down to 150. and it depends how long you have been on it. I have been on effexor over 2 years, and yes, speaking personally, i think i'd rather withdraw from heroin...........Keith
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    Feb 24, 2011 7:12 AM GMT
    icon_lol.gif

    I'm glad I never tried that one.
    I just get "jolts" with mine and an upset stomach when I start up again.
  • novocaine04

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    Feb 24, 2011 7:15 AM GMT
    Hmmm. Still learning about this stuff. But Effexor (venlafaxine) selectively increase both serotonin and norepinephrine levels in the brain. Well compared to Wellbutrin which is only selective to serotonin.

    So once you're finally tapered off venlafaxine, then your body's balance would take back over your levels of norepinephrine. In theory, it should get better, and your symptoms from the withdrawal will decrease. Just takes time icon_smile.gif

    Hope it somewhat helps. Good luck!
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    Feb 24, 2011 8:41 PM GMT
    Keith, I hate to tell you this but you should have never messed with effexor in the first place. I don't know if I'm exactly where you're at, but close and similar. I had been taking fluoxetine for about 3 years, and then about 2 months ago my doc put me on effexor . ...so being on both for a while (low doses) ..I began to just start weaning off both of them (they weren't doing anything) . I did this extremely slowly and under supervision of my psych. I'm talking months.

    I had a huge fucking awful effexor withdrawal - which I think is gone but not sure. It also happened when I tried to come off the last 37.5 gram dose. It was lightheadedness, dizziness, just an awful feeling of blackness that came over me, I felt absolutely horrible. I couldn't move or anything.
    That has all pretty mch passed. But I am still nowhere near normal (how I feel when I feel good). ...I think its from getting off the fluoxetine that I had been on for so long - but part of it could still be effexor related.

    I am TIRED. When I say tired - I mean exhaused, Having a crack cocaine habit for 8 years and suddenly stopping cold turkey EXHAUSTED. I have no energy left in me and am constantly, utterly fatigued. I am DEPRESSED as hell every single day and my body feels like it weighs a thousand pounds every step i take. I am back to extremely negative thinking/ruminations and have gained weight ( though my eating habits have stayed the same). I am extremely moody and irritable and just unpleasant to be around, I hate it, and I get so angry at any thing anymore. These all sound like depression symptoms - not withdrawal. but Idk.

    I think in my case what happened was that my body was sort of used to fluoxetine giving me the serotonin.....so when i pulled that out..it was just this huge shift in neurochemistry - now I have like none..and my body is trying to desperately fill in the gaps, but can't. Basically..I am a hurting bastard now. I have no idea when or if this is going to get any better, or if my body is going to start producing its own serotonin any time soon. I know I'm not the most genetically happy person on this planet but cannot help but think I would not be this bad had I not been ON something...and then been pulled OFF THAT SOMETHING.
    As I can remember, this is the way i started to feel when I hit the age 13 ...when they first started medicating me in the first place. Its awful, because I think this is just how I am. I mean..this is just how I am. Minus all the meds in my system, this is just how I am..imbalanced and depressed and awful feeling. I just don't feel well - at all. I really haven't felt like myself since I was a small child. I don't know what happened to make me all depressed....but it definately had something to do with my father; he was a very miserable and angry bastard. He was very scary and controlling and all that crap. It also had to do with the lousy schools I went to - I got picked on alot and ridiculed. Depression also runs in my family; on my paternal grandmothers side..all up the chain. A bunch of crazy bastards. You should come to a family reunion some time.....all crazy bastards.

    I don't know. I don't know what to tell you other than wait it out. Or get back on something that was working for you (for me - prozac, for you welbutrin).
    I hate to say this but I really don't think I could function in life without some kind of medication. Left to my own devices I am just in an awful state.
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    Feb 24, 2011 8:48 PM GMT
    What does your weaning schedule look like? I took 3 months to go off Cipralex no thanks to my doctor who said I could wean myself off in 2 weeks. My therapist had a conniption that the doctor could be so irresponsible. Take your time and decrease the dose SLOWLY.
  • MisterT

    Posts: 1272

    Feb 24, 2011 9:48 PM GMT
    I've heard horror stories about some of the drugs used and side affects, and coming off some of them. I'd rather deal with depression. I usually can control it myself through intense exercise, though doesn't always work.

    I'm not talking about just slight depression, before anybody says I don't know what real depression is. I've been at points where i was suicidal for long periods of time, I just refused to get put on drugs to treat it.
  • TrentGrad

    Posts: 1541

    Feb 24, 2011 9:54 PM GMT
    RowBuddy saidEffexor is the worst thing on the planet. I will NEVER EVER. EVER go on drugs because of Effexor. IN the end the 9 months of being treated for depression from my stupid job and stupid BF that broke my heart was PURE JOY compared to the 3-4 days of vomiting and laying in bed rolling in pain after my last pill was gone! (even after coming down slowly)

    Try Saint Johns Wort instead


    See, I don't know that you should've ever been on anti-depressants.

    Anti-depressants, IMHO, are for people who suffer a chemical imbalance which causes their depression, anxiety or manic episodes. These people fall into a depression with very little if any actual catalyst.

    In your case, your depression (just as legitimate, let me state that right off) wasn't caused by seemingly a chemical imbalance: it was caused by a couple of traumatic events. I would almost say that you should've been treated with therapy, and if perscribed anything, it likely should've been things to help you with side effects of episodal depression: perhaps gentle sleeping pills if you were having trouble sleeping, or something to help boost your energy, etc...

    DO NOT take St. John's Wort with anti-depressants...it can interact, and as bad as withdrawl symptoms are, you do not want to mess with something like seratonin syndrome or something like that.
  • TrentGrad

    Posts: 1541

    Feb 24, 2011 10:02 PM GMT
    Homowardbound saidMy doc is weaning me off this slowly and I'm also on Wellbutrin (150mgs/day) as the replacement. I am down to 37.5mgs of effexor once every three days now. First day off is ok, second is a bit lite headed and dizzy, third is total fucking crash and burn, light headed dizzy, cunty, postal..I started weaning off 150mgs/day about 30 days ago....

    Can someone tell me it gets better??? jeez, this is killing me.....Keithicon_evil.gif


    It'll get better...you just got to hold out.

    Wellbutrin is a decent medication once you get the hang of it...and it doesn't come with a lot of the same baggage as some of the other meds. Indeed, Wellbutrin is often perscribed now not only for depression...it's also perscribed to negate some of the side effects (notably weight gain and sexual dysfunction) of other medications, as an aid to facilitate weight loss, and under the label Zyban to help smokers quit smoking.
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    Feb 25, 2011 2:20 AM GMT
    Look into 5htp. It is extracted from a plant and is converted by vitamin B6 into 5HT (serotonin). There is no problem passing through the blood brain barrier (like SAMe)...which is costly and wasteful for this reason, if you ask me. However my mom takes SAMe for joint pain and she swears by it, so you may have to try for yourself.

    Taking 5HTP is like shooting a missile of serotonin into your brain. It pretty much absorbs all of it and doesn't compete with other substances to get into the brain. However, its postulated that the problem is not lack of serotonin produced; but in depressed people the uptake of serotonin is too rapid.....so having a surplus shitload of the stuff couldn't hurt is my logic. Read testimonials online; reviews of 5htp. The reviews speak for themselves. It seems to work for a lot of people...it isn't too expensive. Very few side effects. 5HTP is a drug. It is sold over the counter at any vitamin store or GNC.

    I bought some today because I was feeling absolutely like shit. I am actually having a better day - though not sure if its corellary. Time will tell. Don't mix 5HTP with medications. From what I gather this is something you can take sort of like you take any aderall medication..as needed. It gets into your system immediately, not like meds which take weeks to build up. So you can start and stop whenever you like; whenever you need it. There is a residual effect.

    DON'T MIX 5HTP with medications. I am off medications that's why I am trying it.

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    Feb 25, 2011 3:31 AM GMT
    Homowardbound saidMy doc is weaning me off this slowly and I'm also on Wellbutrin (150mgs/day) as the replacement. I am down to 37.5mgs of effexor once every three days now. First day off is ok, second is a bit lite headed and dizzy, third is total fucking crash and burn, light headed dizzy, cunty, postal..I started weaning off 150mgs/day about 30 days ago....

    Can someone tell me it gets better??? jeez, this is killing me.....Keithicon_evil.gif


    I've known so many guys that take wellbutrin as an added twist to the same street drugs wellbutrin is suppose to replace... You might want to try a twelve step program for chemical dependency.

    I was diagnosed both Schizophrenic and Personality Disorder about a year ago and all they give me for it is Seroquel which works incredibly good all by itself. I use to have a wrongful diagnoses all my life for manic depression and bi-polar but, I had to open up finally to my Psychiatrist and admit what was really happening in my mind.

    Remember, Psychiatrists are there for your benefit but, you have to be honest in order for them to really work for you. I use to lie about things just so I could get a really good high on prescription drugs but, I am so much happier now without them.
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    Feb 25, 2011 7:32 AM GMT
    well guys, i appeciate all your well meant and helpful input. Effexor worked very well and quickly for me during a deep bout of suicidal depression a couple of years ago. I had no complaints with it other than it totally dudded my sexual ability to have a decent orgasm. Now, I agree with another physician on a diff thread who asked if you would rather suffer from sexual malfunction or depression.

    The thing I found with Wellbutrin is I can have both the advantage of a/d AND have a decent blow off too. Being a typical oversexed gay man, a proper orgasm is rather important to me.

    Sylas, I hear you brother, call or IM me...I agree with my md that my depression is wired in the womb and hereditary to the males in my family. It is also somewhat situational and can be triggered by negative events. In any event, I'll be popping a pill a day until they plant my sorry ass.

    I have about another 6 weeks of slow weaning and I am finding it is generally the last day that is the worst and really drops me to my knees and makes me say puleese...

    If any of you are considering effexor, talk with your doc and pharmacist and find out all the added bonuses it carries............good mental health to all you guys....to subquote Frazier Crane.......................Keithicon_wink.gif
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    Feb 25, 2011 7:06 PM GMT
    novocaine04 saidHmmm. Still learning about this stuff. But Effexor (venlafaxine) selectively increase both serotonin and norepinephrine levels in the brain. Well compared to Wellbutrin which is only selective to serotonin.


    Wellbutrin does not increase serotonin- so it's a non-SSRI). It works on dopamine and norepinephrine.
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    Feb 25, 2011 8:45 PM GMT
    It has weak action on serotonin. its main action is on dopamine.