HVTN 505 - HIV Vaccine Study

  • Posted by a hidden member.
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    May 05, 2011 8:45 PM GMT
    Is anyone participating in the HVTN505 vaccine study? I do my first injection next week and am wondering what to expect. The only thing that freaks me out a little is that the informed consent says that will be taking 26 vials of blood (which is 1.3 cups!).
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    May 06, 2011 12:59 AM GMT
    sm11222 saidIs anyone participating in the HVTN505 vaccine study? I do my first injection next week and am wondering what to expect. The only thing that freaks me out a little is that the informed consent says that will be taking 26 vials of blood (which is 1.3 cups!).


    I suspect all 26 vials will be over the lifetime of the study.
  • Sparkycat

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    May 06, 2011 2:50 AM GMT
    Since I have no science background I'm wondering how this study works. How can they tell if the vaccine works unless you're exposed to HIV? Sorry if that's a dumb question.
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    May 06, 2011 2:55 AM GMT
    Statistical samples. Some will receive the vaccine, some will receive a placebo. They will compare the rate of infection of the two groups over a period of time, likely including questions about their sexual activities.
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    May 06, 2011 2:55 AM GMT
    ...don't come here for expert advice (see Sparkycat above)...ask the health professionals who are carrying out the trial
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    May 06, 2011 3:37 AM GMT
    sm11222 saidIs anyone participating in the HVTN505 vaccine study? I do my first injection next week and am wondering what to expect. The only thing that freaks me out a little is that the informed consent says that will be taking 26 vials of blood (which is 1.3 cups!).


    1.3 cups is approximately 10.4 fluid ounces. You have about 5-6 liters (169-203 ounces) of blood in your body. Even if they took all 26 vials out at once, you'd be just fine. As the above poster stated, it's probably over the course of the study.
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    May 06, 2011 1:42 PM GMT
    I know it's not much, but 26 vials seems like a lot. It is, unfortunately, taken at one visit.

    The goal of the vaccine study is to determine if the body can create antibodies to the HIV virus. So throughout the study there will be tests to determine the levels of antibodies. This is simply a research vaccine and will never be used amongst the general public. The hypothesis the research team is working with is that a body with HIV antibodies will be better equipped to fight off the infection if one becomes infected.

    There are two types of vaccines. One type, like smallpox, will keep you from (hopefully) from ever contracting the virus. On the other hand, there are vaccines, like the flu vaccine, that may protect you from some strains and, if you are exposed, the symptoms may be less pronounced. The HVTN 505 vaccine falls into that category.

    Like many clinical studies, it is a controlled study. There is an experimental group and a control group. The study is double-blinded until the research is completed, meaning that neither I, nor the researcher knows if I'm receiving a placebo.

    I hope this helps to clarify things a little. If you are interested, you can find the study information on the HVTN website or through the NIH.