An Immune System Trained to Kill Cancer (Re-engineering human cells to attack cancer)

  • Posted by a hidden member.
    Log in to view his profile

    Sep 13, 2011 11:50 PM GMT
    Pretty remarkable.

    http://www.nytimes.com/2011/09/13/health/13gene.html?_r=1&pagewanted=all

    Doctors removed a billion of his T-cells -- a type of white blood cell that fights viruses and tumors -- and gave them new genes that would program the cells to attack his cancer. Then the altered cells were dripped back into Mr. Ludwig's veins.

    At first, nothing happened. But after 10 days, hell broke loose in his hospital room. He began shaking with chills. His temperature shot up. His blood pressure shot down. He became so ill that doctors moved him into intensive care and warned that he might die. His family gathered at the hospital, fearing the worst.

    A few weeks later, the fevers were gone. And so was the leukemia.

    There was no trace of it anywhere -- no leukemic cells in his blood or bone marrow, no more bulging lymph nodes on his CT scan. His doctors calculated that the treatment had killed off two pounds of cancer cells.

    A year later, Mr. Ludwig is still in complete remission. Before, there were days when he could barely get out of bed; now, he plays golf and does yard work.
  • commoncoll

    Posts: 1222

    Sep 14, 2011 12:21 AM GMT
    Wow! Pretty amazing. They have tried suicide gene therapy using thymadine kinases of HSV-1 (herpes simplex virus) and hepatitis B viruses and HIV-1 Tat along with other cells that have proteins that allow other cells to be translocated once they are tied together for cancer cell apoptosis. But I think there was only limited success with that with HIV-1 Tat being the most productive.

    This is a very nice breakthrough.
  • Posted by a hidden member.
    Log in to view his profile

    Sep 14, 2011 12:32 AM GMT
    Thanks for posting this. I have 2 doctors in my family and would love to talk to them about this.
    Everyone I know has had a family member contract cancer or have had a death in their family due to it. Knock on wood, no one in my family has had it. (That we know of anyway.)
    Hopefully scientists will be able to modify this to treat all forms of cancer sooner than later!
    Thanks again.
    Tristan
  • Posted by a hidden member.
    Log in to view his profile

    Sep 14, 2011 12:39 AM GMT
    http://xkcd.com/938/

    t_cells.png
  • commoncoll

    Posts: 1222

    Sep 14, 2011 12:54 AM GMT
    paradox saidhttp://xkcd.com/938/

    t_cells.png

    Forms of viruses like HIV-1, HSV-1, and Hepatitis B used in gene therapy are not disease causing agents anymore.

    Like I said in my post, I don't understand things exactly, but the main gist is that 11 amino acids from the protein coating of HIV-1 are taken and are attached to the T-cells. Those amino acids have the ability to translocate in the cancer cells and take therapeutive agents- ACV (I forget what it stands for) to the cells. The cells then die and you kidneys pick up the waste.
  • Posted by a hidden member.
    Log in to view his profile

    Sep 14, 2011 6:23 AM GMT
    This reminds me of the beginning to I Am Legend

    Reporter: (To Doctor) "So what you're saying is...you've found the cure to cancer?"

    Doctor: "Yes, we have =D"

    CUT TO THE ENTIRE GLOBAL POPULATION DEAD DUE TO UNFORESEEN SIDE EFFECTS.
  • Posted by a hidden member.
    Log in to view his profile

    Sep 14, 2011 12:33 PM GMT
    Ariodante saidThis reminds me of the beginning to I Am Legend

    Reporter: (To Doctor) "So what you're saying is...you've found the cure to cancer?"

    Doctor: "Yes, we have =D"

    CUT TO THE ENTIRE GLOBAL POPULATION DEAD DUE TO UNFORESEEN SIDE EFFECTS.



    Those are my exact same thoughts when I read about this!

    Hollywood has gotten me scared of anything related to mutated virus or artificial intelligence. LOL!
  • Posted by a hidden member.
    Log in to view his profile

    Sep 14, 2011 3:10 PM GMT
    Very interesting! Hope the research will bear fruit especially for the masses icon_smile.gif