Should I participate in a HIV vaccine trial?

  • Posted by a hidden member.
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    Jan 07, 2012 7:21 AM GMT
    I was selected for a trial of a HIV vaccine that has been through the safety trials and another trial for the past 10 years. Now they are doing the trials on how effective it is. Basically from what i gather they inject 2 "man made" proteins that assist your immune system to ultimately be immune to HIV.

    It's a paid gig and I have a follow up phone call on monday to see if i would like to join in. They give you the vaccine and for a year they test u for HIV once a month a u continue ur regular life (they dont make u partake in anything risky).I was told they can tell from bloodwork when youve had contact with HIV and not necessarily contracted it.

    A part of me wants to be a tool in finding a cure or vaccine for HIV but another part of me thinks this whole trial stuff is scary.

    I was reassured that within the 10 years these trials have been going on there have been no reported side effects.

    What do u guys think?

    Has anyone participated in a trial before?
  • Posted by a hidden member.
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    Jan 07, 2012 7:26 AM GMT
    I would probably do it. If it works, it's free vaccination AND you get paid.
  • Posted by a hidden member.
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    Jan 07, 2012 7:29 AM GMT
    Honestly, it's your life in your hands.

    The worst is the drugs don't actually work, or have an opposing effect on your body.

    The best is you become immune and if you contract HIV it will never turn into AIDS and get paid.
  • hotkj2002

    Posts: 64

    Jan 07, 2012 7:34 AM GMT
    Dont do it..... unless you are raw dawging it then I guess you should.
  • MikemikeMike

    Posts: 6932

    Jan 07, 2012 7:39 AM GMT
    ur profile states you're 24 and negative. Do you need the money that bad?? All medications have side effects all. What if it does something to impair your immune system??. Ask more questions. Read the release paperwork your signing. It's your life.icon_idea.gif
    Test sounds bogus because they can't follow you 24-7 to see if you have sex protected or otherwise. Chimps share 99% of our DNA. Has this injectable worked on them?? They can control their sexual behavior and monitor them 24 -7.icon_idea.gif
  • Suetonius

    Posts: 1842

    Jan 07, 2012 9:45 AM GMT
    If the vaccine works, it might protect you from ever contracting HIV; and it might not. What have they told you about the antibody status you will have after the test? Will this vaccine induce a response causing your body to produce antibodies? If so, it is likely that you will always test positive for HIV in the future (on the antibody test), even though you never actually had HIV. That might be problematic if you ever apply for medical or life insurance (if you ever apply for life insurance that is not guaranteed issue, today they take a swab from your mouth, which would probably show up as HIV antibody positive), apply to join a police, fire, or military service, or apply for any job for which they give you a physical exam. Even though it might be illegal - and it is not in most states - (I didn't look - are you in the USA?) whoever it was would likely not hire you/accept your application/issue insurance, because you tested positive for HIV. If asked, they would simply deny that HIV+ status was the reason, and come up with some other reason.
    I wonder why they are asking men in 1st world countries to be test subjects, when a lot of this vaccine effectiveness testing is normally done in 3rd world countries where men have unprotected sex (raw) all the time, and are much more often exposed to HIV transmission.
  • Posted by a hidden member.
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    Jan 07, 2012 2:26 PM GMT
    Would you engage in risk-behaviour if vaccinated that you would otherwise have avoided? Then don't. If you are still going to play safe then go for it.
  • Posted by a hidden member.
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    Jan 07, 2012 2:31 PM GMT
    I wouldnt start a barebacking safari if i got the vaccine, i have too much HIV anxiety to do that.

    I'm not desperate for the money, I dont even know how much they pay, I just think it'd be cool if it works to be a player in the breakthrough :-D

    A good point was brought up about testing positive for the rest of my life. I'll have to ask when i get the callback.

    Thanks for everyones input icon_smile.gif
  • DukeAtreides

    Posts: 64

    Jan 07, 2012 2:34 PM GMT
    Having done some work in medical research my advice would be this: Ask them. Studies conducted in the United States have to undergo strict review for ethical standards. One of those standards is giving you time to ask questions. So tell them your concerns - they have probably anticipated them and have some answers for you.
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    Jan 07, 2012 2:34 PM GMT
    I am a clinical research coordinator and I recently looked at a very similar study. Ask for the consent ahead of time and THOROUGHLY read it! The HIV vaccine study that I was reading the consent for stated that the vaccine could potentially cause cancer (one sentence in a 17 page document). It also stated that no compensation would be provided for any long-term damage that could result from the vaccine/vaccine administration. The compensation was $500+ for participating in the study but my health is obviously worth more to me than that.
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    Jan 07, 2012 5:44 PM GMT
    I would do it but my people are already immune to it.
  • Posted by a hidden member.
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    Jan 07, 2012 6:55 PM GMT
    I participated in a HIV vaccine study in the early 90's in Seattle. I had to go to the hospital to get tested every couple of weeks. There was no chance that I was going to contract the disease during the trial and the doc knew that as I was with the man I am still with and monogamous. They were not paying people back then, it was totally voluntary. I wanted to do it because I had lost so many friends over the years to AIDS. The whole process was perfectly safe. We attended a couple of classes before the vacine was first given and all our questions were answered.

    go for it.
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    Jan 07, 2012 8:39 PM GMT
    I participated in a trial before, but it wasn't a vaccine trial.
    It was a drug trail for ABT378, which later became Kaletra.

    I didn't take the study drug though. I was randomly assigned to the other group and I took a whole bunch of other drugs instead. It made me so sick that I dropped out of the study before the 48 weeks as over, and didn't go back on meds again until I had full blown AIDS with pneumonia and 60 T cells. Thanks to my contribution, Kaletra was shown to be more easily tolerated than the alternative. Some of the components of which have since been discontinued they were so bad and/or ineffective. What I was taking before the study did not bring my viral load undetectable, so I probably would have changed regimes anyway. During the study, drugs and labs and checkups were free.

    In contrast, you are considering a vaccine trial where 10 years of research has shown minimal negative side effects. Michelle Bachmann says that Gardisil makes people retarded. Only you can weigh your own tolerance for risk with your desire to contribute to the advancement of science.
  • Posted by a hidden member.
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    Jan 07, 2012 8:42 PM GMT
    nope, vaccines are horrible for you.
  • camfer

    Posts: 892

    Jan 07, 2012 8:50 PM GMT
    intentsman saidMichelle Bachmann says that Gardisil makes people retarded.


    She must have had a really large dose.
  • Suetonius

    Posts: 1842

    Jan 07, 2012 8:54 PM GMT
    camfer said
    intentsman saidMichelle Bachmann says that Gardisil makes people retarded.

    She must have had a really large dose.

    Michelle knows that Gardisil makes people retarded, because some woman told her that it happened to her daughter after she was vaccinated.

    Apparently she really trusted this woman, because it was her mother.
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    Jan 07, 2012 8:55 PM GMT
    Trollileo said
    Haaretz saidI would do it but my people are already immune to it.
    We are?


    Don't you have your jar of gypsy tears?
  • Posted by a hidden member.
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    Jan 07, 2012 8:57 PM GMT
    Trollileo said
    Haaretz saidI would do it but my people are already immune to it.
    We are?


    Some people don't have CCR5 receptors and are immune to those strains of HIV which bind exclusively to CCR5.
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    Jan 11, 2012 7:47 PM GMT
    Sounds like a great idea, seems like its far down the pharma phases as they are now looking at effectiveness in humans, and its a bonus if it immunises you!!! Dont worry about side effects, they are very unlikely and if theyve passed phase 1 trials which by the sound of it they have if they are testing efficacy and not just the metabolism and tolerance for the drug (which is done in phase 1 on healthy volunteers.). If it had bad side effects, they would not have passed the first phase and the drug would be scrapped.

    VERY valid point about the whole testing +ve due to antibody genesis, definately bring that up at the call back, hadn't even thought about that. That was very clever thinking on his part.
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    Jan 11, 2012 7:59 PM GMT
    Something about this smells very fishy....and I'm not talking about the fish you find at the "Seafood" area of the store.

    I would be VERY skeptical of this. I've always went by this phrase "Tests are for lab rats, NOT for humans." I would research this thoroughly before agreeing to anything. I would want to know exactly what it is I'm getting into before doing it. I would wanna know what it is they're exactly gonna do. Is it really just a simple bloodtest and that's it? What is it exactly are they doing?

    I would also read, and reread the "fine print" before even signing my name onto this thing. Before I sign anything, I ALWAYS make sure that I know what it is I'm up against. Ask as many questions as you can to these people who are going to do this. Before you sign your name to anything, know everything you need to know, and once you have a good understanding, THEN you can think about signing your name.

    I can't tell you how many times I've been cheated by signing my name to something. Be careful...that's my advice.
  • jim_sf

    Posts: 2094

    Jan 11, 2012 8:08 PM GMT
    divvy198509 saidSounds like a great idea, seems like its far down the pharma phases as they are now looking at effectiveness in humans, and its a bonus if it immunises you!!! Dont worry about side effects, they are very unlikely and if theyve passed phase 1 trials which by the sound of it they have if they are testing efficacy and not just the metabolism and tolerance for the drug (which is done in phase 1 on healthy volunteers.). If it had bad side effects, they would not have passed the first phase and the drug would be scrapped.


    This. The early phases of any human drug or vaccine trials are there to determine whether or not the stuff in question is safe enough for use - not flawless, but acceptably close. Your (OP's) personal risks are minimal, but not zero; it's up to you to decide whether or not that's acceptable for you, given what the vaccine could do for you personally and for humanity as a whole.

    divvy198509 saidVERY valid point about the whole testing +ve due to antibody genesis, definately bring that up at the call back, hadn't even thought about that. That was very clever thinking on his part.


    That'd be a positive on ELISA, but a routine follow-up Western blot would only detect the appropriate proteins and not the virus itself. If the vaccine is effective and goes into production, then I'm certain that testing regimens would be updated to distinguish between "has vaccine immunity" and "has HIV".
  • MikemikeMike

    Posts: 6932

    Jan 12, 2012 8:03 AM GMT
    ClevelandTown saidI am a clinical research coordinator and I recently looked at a very similar study. Ask for the consent ahead of time and THOROUGHLY read it! The HIV vaccine study that I was reading the consent for stated that the vaccine could potentially cause cancer (one sentence in a 17 page document). It also stated that no compensation would be provided for any long-term damage that could result from the vaccine/vaccine administration. The compensation was $500+ for participating in the study but my health is obviously worth more to me than that.


    Agreed- what I said too, but he put it much more clinically so Ii hope you re-read this Horrogymguyicon_idea.gif
    If its just for the money there are so many companies looking for product testing. Girls in my office did toothpaste and got 250.00. Not risky to their immune system.icon_idea.gif
  • Posted by a hidden member.
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    Jan 14, 2012 2:59 PM GMT
    Haaretz said
    Trollileo said
    Haaretz saidI would do it but my people are already immune to it.
    We are?


    Don't you have your jar of gypsy tears?



    LOL.....And here I thought you could trace your past relatives to survivors of the black plague and thus you were really capable if immunity.
  • Posted by a hidden member.
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    Feb 02, 2012 1:00 PM GMT
    MikemikeMike saidur profile states you're 24 and negative. Do you need the money that bad?? All medications have side effects all. What if it does something to impair your immune system??. Ask more questions. Read the release paperwork your signing. It's your life.icon_idea.gif
    Test sounds bogus because they can't follow you 24-7 to see if you have sex protected or otherwise. Chimps share 99% of our DNA. Has this injectable worked on them?? They can control their sexual behavior and monitor them 24 -7.icon_idea.gif


    +1