Mar 31, 2012 5:06 AM GMT
"Allergic diseases have reached pandemic levels," begins David Artis's new paper in Nature Medicine. Artis goes on to say that, while everyone knows allergies are caused by a combination of factors involving both nature and nurture, that knowledge doesn't help us identify what is culpable—it is not at all clear exactly what is involved, or how the relevant players promote allergic responses.
There is some evidence that one of the causes lies within our guts. Epidemiological studies have linked changes in the species present in commensal bacteria—the trillions of microorganisms that reside in our colon—to the development of allergic diseases. (Typically, somewhere between 1,000 and 15,000 different bacterial species inhabit our guts.) And immunologists know that signaling molecules produced by some immune cells mediate allergic inflammation.
Animal studies have provided the link between these two, showing that commensal bacteria promote allergic inflammation. But these researchers wanted to know more about how.
To figure it out, Artis and his colleagues at Penn's School of Veterinary Medicine treated mice with a broad range of oral antibiotics to diminish or deplete their commensal bacteria and then examined different immunological parameters. They used a combination of five different antibiotics, ranging from ampicillin, which is fairly run of the mill, to vancomycin, which is kind of a nasty one.
They found that mice treated with antibiotics had elevated levels of antibodies known to be important in allergies and asthma (IgE class antibodies). The elevated antibodies in turn increased the levels of basophils, immune cells that play a role in inflammation, both allergic and otherwise.