Odd coincidence, I just wrote about this same topic in another thread here a few hours ago. One of my college degrees is in Speech, I've appeared on TV and been a radio DJ, I taught HS & college, and my Army Officer's career required me to speak authoritatively before large assemblies of soldiers all the time.
Every person is different, so what works for one may not work for another. But here's what helps me:
If the lighting permits, I look right into the eyes of my audience. For me, it makes it more like a private conversation, and I forget that there may be over 1000 others present. I'm at my worst when strong stage lighting blinds me, so that all I can see is a black wall in front of me, and little or nothing of the audience, making me effectively blindfolded. If their eyes still spook you, focus on their hair. At a distance it will still seem to them that you're looking into their eyes.
To accomplish this eye contact I rehearse my copy, so I know it virtually by heart. I NEVER keep my head down, reading before a live group or TV camera. That annoys & insults your audience, and prevents you from making that eye contact. You SPEAK to them, like you do with friends. Your copy is just for a glancing reference, not to read from word-for-word. You will have more receptive & appreciative listeners if they see you looking right at them.
I also make sure my copy is in a very big font, easy to create with computers. If the copy was given to me from some other source I'll retype the whole thing, adding new double-spaced paragraph breaks that help my delivery. I also increase the regular line spacing to 1.5. Remember, on a podium your copy will be at about arm's length, not like holding up a book or magazine, and so you should practice this way.
I hand annotate my copy in red for emphasis, to remind me what words I want to stress, where to pause, where to raise my voice, etc. There are standard guides for this marking, but just make up your own. When retyping I also will use my own phonetic spelling of awkward or unusual words, and all numbers are also spelled out, for instance 9 = nine. And I use no abbreviations, other than contractions, so that something like "Mr." is written out fully as "Mister". Most people find it easier to read aloud that way, with fewer stumbles.
My pages are all numbered top and bottom, TV & radio script style for easy glancing. This is simple if you use your word processor's Header & Footer features. The top and bottom of your pages should look like this:
2...2...2...2...2...2...2...2...2...2...2...2...2...2 and so forth for each page
Speak at a slower pace than conversational, especially if you aren't being amplified and have to raise your voice. People can't process audible information well when it's booming around a large space, it all runs together to their ears, so add pauses between words.
Depending on circumstances, I also like to walk around on the stage or the floor, even go out among the audience if I can. I HATE staying glued behind a podium. If I need it I'll carry my script pages with me, or have it on large index cards. Beware of assuming a white-knuckle grip on the sides of the podium, a give-away to the audience that you are scared shitless.
Smile as much as the material allows, and insert apparently impromptu, off-the-cuff remarks, comic when appropriate, even if you have preplanned them. It will relax you, and tell the audience you're at ease & confident.
If you decide a formal script is not appropriate, and you'd rather speak extemporaneously, then at least make bullet notes on index cards of the points you want to make. This will keep your presentation in a logical order, and avoid the dreaded: "Oh, I forgot to mention..." as you're leaving the podium or the audience is exiting.
Please contact me directly with any additional questions.