Any one taking R alpha-lipoic acid?

  • Posted by a hidden member.
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    May 06, 2012 11:47 PM GMT
    men can built up too much iron in the body as they age (women bleed and do not have this problem) --- This supposed to chelate iron and other heavy metals. Any experience?
    http://en.wikipedia.org/wiki/Lipoic_acid
  • tautomer

    Posts: 1010

    May 07, 2012 12:11 AM GMT
    I would not mess with any chelating agents unless your doctor prescribes it to you. It's very easy to overdue it and cause serious health effects from it. It's actually very easy to test for someone having too much iron. If you have it, you either take these types or agents, or you have to donate blood every few weeks or so.
  • BlackBeltGuy

    Posts: 2609

    May 07, 2012 12:51 AM GMT
    I have been taking R-alpha lipoic acid and Acetyl L-carnitine religiously since 2009.
    It helps with blood sugar and extremely potent antioxidant and anti aging qualities.

    I would like to say taking both...it helps you focus, memorize better and it's excellent for cardiovascular health.

    haven't had a cold in years or the flu

    my doc told me this. Also, he said make sure it is R-alpha lipoic acid
    not just alpha lipoic acid. he said the R-ala is the best and most potent stuff

    100mg RALA
    500mg Acalean

    any other questions hit me up. I put my whole family on it too
  • Posted by a hidden member.
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    May 07, 2012 1:07 AM GMT
    Alpha-lipoic acid is in one of the supplements that I take, but I can't say I've noticed a huge difference. Do you think you have a build up of too much iron? I wouldn't trying chelating without consulting a doctor. Chelation takes out the good along with the bad. You may need to adjust your other supplements to prevent having a deficiency.
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    May 07, 2012 1:43 AM GMT
    R-lpa is a very weak iron chelating agent. It's not normally used to chelate anything. It might if takes in enormous quantities... But the other benefits of taking it seems real.
  • tautomer

    Posts: 1010

    May 07, 2012 2:07 AM GMT
    precurser4t saidR-lpa is a very weak iron chelating agent. It's not normally used to chelate anything. It might if takes in enormous quantities... But the other benefits of taking it seems real.


    Ah, in that case, have at it!
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    May 07, 2012 5:14 AM GMT
    I've been taking alpha lipoic for years, also CLA Tonalin besides the ordinary multi & omega and last year or two years ago I added b complex.

    Pretty much anything that's supposed to be good for the brain, having watched my mother's deteriorate so horribly. Hope I'm not hurting myself with this stuff. For a while major doses of vitamin E was being touted by science as an Alzheimer's preventative, so mom took it, but after she died, science decided, ooops, actually major dosing is worse for you.

    All you can do is go with what seems to be the best knowledge at the time, I suppose.

    Per Blackbeltguy's post I just checked out http://en.wikipedia.org/wiki/Acetylcarnitine
    "ALCAR has the ability to cross the blood-brain barrier and get to the brain blood circulation, where it acts as a powerful antioxidant,[14] which helps in prevention of the brain cells' deterioration. Its supplementation has been shown to be neuroprotective "

    Will study that further and check with an aging studies professor from a class I took last year who specializes in the deterioration of the brain.
  • Posted by a hidden member.
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    May 07, 2012 5:17 PM GMT
    Iron accumulation that occurs with aging has been incriminated in neurodegenerative diseases like Alzheimer's and Parkinson's. Iron accumulation may also contribute to muscle loss that occurs in elderly (sarcopenia). Iron accumulation causes oxidative stress and inflammation that results in cell damage. Hopefully alpha-lipoic acid ( a potent antioxidant which is uniquely both fat and water soluble ) will combat this damage. Alpha- lipoic has been shown to reduce iron accumulation in the brains and muscles in rats. I'm not aware of any human studies.
    There are several types of chelation. The first is the treatment of heavy metal posioning. A chelating agent is used to remove the heavy metal from the body. There is also a chelation therapy done by a few practitioners of alternative medicine. http://www.quackwatch.com/01QuackeryRelatedTopics/chelation.html
    Both of these therapies require a physician to monitor.
    Using alpha-lipoic acid to reduce iron does not fit into these two categories.
    I use alpha-lipoic in a hope that it may slow down the aging process. Only time will tell.
  • Posted by a hidden member.
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    May 07, 2012 5:18 PM GMT
    I don't do drugs, but I'd do you! icon_twisted.gificon_wink.gificon_cool.gif
  • Posted by a hidden member.
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    May 14, 2012 5:57 PM GMT
    I would prefer to take RALA over just regular ALA; but I find RALA to be really cost prohibitive... icon_sad.gif

  • metta

    Posts: 39075

    May 14, 2012 6:11 PM GMT
    FirstKnight said http://www.quackwatch.com/01QuackeryRelatedTopics/chelation.html




    from that link:

    "The few well-designed studies that have addressed the efficacy of chelation for atherosclerotic diseases have been carried out by "establishment " medical scientists. Without exception, these found no evidence that chelation worked.

    Based on numerous reviews of the world's medical literature, these same conclusions have been reached by the FDA, the FTC, National Institutes of Health, National Research Council, California Medical Society, American Medical Association, Centers for Disease Control and Prevention, American Heart Association, American College of Physicians, American Academy of Family Physicians, American Society for Clinical Pharmacology Therapeutics, American College of Cardiology, and American Osteopathic Association."


    It sounds like it might be a waste of money.
  • Posted by a hidden member.
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    May 20, 2012 12:43 PM GMT
    Over supplements can hamper thee liver functioning
    moreover its said that exo-sources of that supplement are poorly absorbed by the blood !
  • musclmed

    Posts: 3270

    Jun 25, 2012 12:56 AM GMT
    xybender saidR-lpa is a very weak iron chelating agent. It's not normally used to chelate anything. It might if takes in enormous quantities... But the other benefits of taking it seems real.



    Sorry your statement is WRONG

    Toxicology 1990
    R-Alpha Lipoic converts to R-Dihydrolipoic acid, which contains two thiol groups. Thiol groups chelate (capture) mercury, lead, and remove them from the body. An ideal heavy metal chelator should be able to enter the cell easily, chelate the heavy metal and increase their excretion without redistribution to other organs or tissues.
    Toxicology 1990;62:1-25.

    R-Dihydrolipoic Acid, because it can pass through cellular membrane, easily reaches the mitochondria, where it shifts -SH-S-S- to the reduced state, thus, also improving the cellular energy homeostasis.
    Archives of Biochemistry and Biophysics, 1991 Aug 1;288(2):609-13.

    Daily supplementation of R-Alpha Lipoic Acid reached all areas of the central / peripheral nervous system and decreased lipid peroxidation in brain, sciatic nerve tissue and it decreased lipid peroxidation in brain tissue about 50%.
    Neurotoxicology 2001;22:577-592.
    Free Radical Biology Med 1995;19:227-250.
    Human & Experimental Toxicology 1998;17:225-230 46.
    Free Radical Biology & Medicine 1997;22:359-378.

    R-Alpha Lipoic Acid is a universal anti-oxidant, the only antioxidant capable of functioning in fat (cellular membranes) and aqueous (blood) environment.
    Free Radical Biology & Medicine.1995 Aug;19(2):227-50.





    Alpha lipoic acid sold in stores contains the stereo isomers R and L alpha lipoic acid

    The Right and Left handed molecule.

    When you buy Alpha lipoic acid about 40-50% is the R type.


    Almost all of the research in Alpha Lipoic acid in the future will involve the pure R molecule.
    The mechanism is based on oxidation and regeneration of antioxidants. The heavy metal issue is yet to be proven.

    The R type is thought to have less side effects, but generally the same anti oxidant benefits.

  • Posted by a hidden member.
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    Jun 25, 2012 12:57 AM GMT
    No. I've got enough biological and drug induced mental issues. I don't need anymore thank you.