CK Levels Elevated?

  • Posted by a hidden member.
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    Aug 10, 2007 1:49 AM GMT
    Not sure if this is the right forum, but as this is about health thought I would post here.

    Has anyone had their CK Levels checked especially after working out or the day after? From what I am seeing is that the CK Levels will increase dramatically after working out.

    I'm on Lipitor for High Cholesterol and have been for about a year now. Every 3 months getting a blood test as required by the Dr. I started working out 4 weeks ago and just got my blood results back with extremely high CK Levels. They went from around 800 to 5700. At this level, you are at risk for either a heart attack or kidney failure. By Dr. orders, I stopped the Lipitor and am getting more tests done. He now tells me to stop working out so he can find out what is elevating these levels. I have absolutely no symptoms and feel fine. From looking on the web, this may all be due to working out. I was just curious if anyone else has run into this?

    I guess the Doc has never run into anyone who works out and is on Lipitor before?
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    Aug 10, 2007 4:01 AM GMT
    I am not a physician, but I do know something about biochem and work outs..

    I can tell you that CK, or creatine kinase, is a protien enzyme that helps to attach a phosphate group to creatine. Creatine phosphate is a phosphate carrier responsible for donating this high energy phosphate group to make ADP (adenodiphospate) into ATP (adenotriphosphate). When ATP looses one of its phospate groups, it releases energy for your muscles to utilize before it becomes ADP..

    When you work out, a lot of the CK is loss into the blood stream... This is considered a byproduct of muscle damage... This is true for any skeletal or cardic muscles. That is why you sometimes read CK values to assess a heart attack/MI... When you exercise, you will also increase your blood CK level from the skeletal muscles...

    That is why it would not be a clean CK test if you work out a lot... It is like eating a large sugary meal then have your blood sugar checked for diabetis... You do not know what is causing the spike, and the idea is to get the baseline values...

    I hope this helps...
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    Aug 10, 2007 4:11 AM GMT
    Forgot to point out, heart attacks still primary use troponin (specific heart enzyme) and sometimes myoglobin (oxygen carrying moelcues in the muscles) values as a diagnositc tool..
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    Aug 10, 2007 4:29 AM GMT
    One of the uncommon, but potentially dangerous, along with hepatoxicity, side effects of lipitor is myopathy and possibly rhabdomyolysis which will cause an elevated CK because this process breaks down skeletal muscle, and this is probably why the CK was ordered in the first place in relation to being on lipitor. CK, as NYCmuscle noted, is associated with muscle muscle damage and breakdown, but there are many things that can cause an elevated CK, and yes, it would be important to find the cause, and also stop any possible inciting factors while working on finding the cause.

    Yes, a heart attack will raise your CK, but so will many other things, and there are much more specific tests for a heart attack. With rhabdomyolysis, which is rapid pathologic breakdown of the muscle, the kidneys have to filter the products of the breakdown, and can basically be overwhelmed and fail.

    So the responsible thing is, as your physician has done, stop the lipitor stop the working out, and try and figure out what is causing the elevated CK because it might be something serious and you can't just brush it off and say it is from the working out.
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    Aug 10, 2007 4:43 AM GMT
    what does your ecg show?

    what other bloodwork have they done concurently, ie troponins and mg++ k+ and renal function for example.

    may as well get a complete cardiac work up done to establish a baseline.
    maybe you need to do the stress test, get an US etc.
    be well my friend

  • mtnsky

    Posts: 17

    Aug 10, 2007 4:57 AM GMT
    Haha, this is my username on here. Creatine phosphokinase is the enyzme that shuttles creatine between back and forth between its phosphorylated form. Skeletal muscle is chock full of it. If there is any type of trauma to muscle fibers, it will be released into the blood and will show up as elevated. It doesn't take at all to cause an increase...bumping into a wall can do it.

    It's a measure for things such as wasting diseases and actual muscle damage. Another sequelae to look for in actual muscle damage is myoglobin in the bloodstream and in the worst case, destroying the kidneys and turning urine a brownish red.
  • mtnsky

    Posts: 17

    Aug 10, 2007 4:57 AM GMT
    Edit: beaten
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    Aug 18, 2007 10:22 PM GMT
    Just an update, I went off Lipitor immediately by doctors instructions (been about a month now) and after 2 weeks of not working out (I miss it) and more blood tests to verify everything - my CK levels are now down to 211 from 5700. He now believes it is because I was working out with a trainer during the time I took my blood test. This is what I told him from the beginning, as I had no problems or symptoms and working out with a trainer was the only difference between this blood test and the ones prior.

    I still have one more blood test to go and I'm back at the Gym. But it looks like this was elevated due to me working out and the Doc got scared. He did other blood tests as well, as mentioned above Myo-something-or-nother and others and all were fine.

    Thanks for all your input!