I actually do think Biden will do very well. In many ways, he's the most popular of all the prominent politicians right now. I also think Obama will do much better in the next two debates. I think Romney did so much flip-flopping last night that it threw Obama for a loop, but he won't let that happen again.
Romney dodged all of Obama's assertions about his horrible budget plans, and his jab at Obamacare being partisan is just crap; Informed Americans know that republicans were being obstructionists in congress, not because they didn't want to pass anything, but because they were trying to defeat Obama. They made it personal and gambled with the lives of Americans, and Obama needs to make it clear who he's fighting for versus who Mittens answers to.
I think Obama will be able to reevaluate how he needs to handle Romney, and we'll see a very different outcome in the next two presidential debates.