Genetically Modified Humans

  • metta

    Posts: 39107

    Oct 10, 2012 9:49 PM GMT


    Genetically Modified Humans

    http://blogs.scientificamerican.com/guest-blog/2012/10/04/warning-genetically-modified-humans/
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    Oct 10, 2012 10:28 PM GMT
    If they start altering genes, no man will be able to walk.
  • djvan

    Posts: 8

    Oct 16, 2012 2:20 AM GMT
    I'm going to have a difficult time with this post. I feel like I need to post my personal statement and call it good. In short, I came up with the the idea of gene therapy during a prof's lecture - just wasn't the first person to do it - and I've been an advocate since.

    I truly believe that gene therapy is the answer to many of our genetic diseases. Yes, the technique could be used for cosmetic purposes, but that's a hurdle society will have to decide to jump over when the time comes. There are so many diseases that could be CURED - not treated - through gene therapy.
  • Medjai

    Posts: 2671

    Oct 16, 2012 2:35 AM GMT
    djvan saidI'm going to have a difficult time with this post. I feel like I need to post my personal statement and call it good. In short, I came up with the the idea of gene therapy during a prof's lecture - just wasn't the first person to do it - and I've been an advocate since.

    I truly believe that gene therapy is the answer to many of our genetic diseases. Yes, the technique could be used for cosmetic purposes, but that's a hurdle society will have to decide to jump over when the time comes. There are so many diseases that could be CURED - not treated - through gene therapy.


    But at the same time, when messing with genetics, there is so much that can go wrong too...
  • ThatSwimmerGu...

    Posts: 3755

    Oct 16, 2012 2:47 AM GMT
    When genetically notified humans have kids, how would that turn out? It seems like a few generations of modified humans would be needed before anything more happens.
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    Oct 16, 2012 2:51 AM GMT
    Remember how many mistakes it took Edison to get to the LIGHT BULB!?

    This scary to me like, "The Island Of Doctor Moreau" scary... Or even the idea farming clones for spares... someday it may happen, and someday still someone will forget how their lives ever got so easy....icon_neutral.gificon_neutral.gificon_question.gif
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    Oct 16, 2012 2:53 AM GMT
    NormalGuy93 saidWhen genetically notified humans have kids, how would that turn out? It seems like a few generations of modified humans would be needed before anything more happens.

    Answers can only be based in theories, not in facts, as Humans have yet to be cloned out of their humanity....
  • Medjai

    Posts: 2671

    Oct 16, 2012 2:57 AM GMT
    JR_RJ saidRemember how many mistakes it took Edison to get to the LIGHT BULB!?

    This scary to me like, "The Island Of Doctor Moreau" scary... Or even the idea farming clones for spares... someday it may happen, and someday still someone will forget how their lives ever got so easy....icon_neutral.gificon_neutral.gificon_question.gif


    Edison didn't invent the lightbulb. He just marketed it.

    I just see us getting ahead of ourselves. Dabbling in what we don't understand fully, without sufficient study into the long term. We see it all the time with things that are invented, approved, then banned a decade later. See DDT, asbestos, mercury fillings, lead paint, leaded gas, etc. It's shortsighted. Especially with genetics. Onc that becomes mainstream, the effects can never be foreseen or taken back. At least not with current technology.
  • Montague

    Posts: 5205

    Oct 16, 2012 2:58 AM GMT
    We have to start sometime and it might as well be today!
  • araphael

    Posts: 1148

    Oct 16, 2012 3:02 AM GMT
    metta8 said

    Genetically Modified Humans

    http://blogs.scientificamerican.com/guest-blog/2012/10/04/warning-genetically-modified-humans/


    You can not stop science. This is the future. But I always take comfort in the fact that nature has a way of checking the advances of science. For example, science comes up with a cure for something then nature alters itself to resist the cure. It all balances out.
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    Oct 16, 2012 4:25 PM GMT
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    Oct 16, 2012 4:45 PM GMT
    Medjai said
    JR_RJ saidRemember how many mistakes it took Edison to get to the LIGHT BULB!?

    This scary to me like, "The Island Of Doctor Moreau" scary... Or even the idea farming clones for spares... someday it may happen, and someday still someone will forget how their lives ever got so easy....icon_neutral.gificon_neutral.gificon_question.gif


    Edison didn't invent the lightbulb. He just marketed it.

    I just see us getting ahead of ourselves. Dabbling in what we don't understand fully, without sufficient study into the long term. We see it all the time with things that are invented, approved, then banned a decade later. See DDT, asbestos, mercury fillings, lead paint, leaded gas, etc. It's shortsighted. Especially with genetics. Onc that becomes mainstream, the effects can never be foreseen or taken back. At least not with current technology.

    Can't master genetics without first failing at it, so many times over... and where do we draw that pesky line we call Humanity-Sentient and a "clone" or consciousless organs?
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    Oct 16, 2012 4:47 PM GMT
    Aristoshark said
    JR_RJ said
    This scary to me like, "The Island Of Doctor Moreau" scary...

    Hey I saw that movie. The remake, where Marlon Brando played the island.

    I want to see all these! The remake in the late 90's scared me shitless... goes to show what actually is Scary to me. icon_eek.gificon_confused.gif
    http://www.imdb.com/title/tt0116654/
  • djvan

    Posts: 8

    Oct 19, 2012 11:23 PM GMT
    There are many clinical gene therapy trails that have already been completed, and that are currently underway. The first big success was the DeSilva trial, which treated a young girl suffering from ADA deficiency, a form of SCID. There are also failures - the Gelsinger trial comes to mind.

    However, this research will continue to be carried out because people are suffering. We (researchers and patients) want a cure for their diseases. The current treatments for many of the diseases being treated with gene therapy (if there even is a treatment) are inadequate and and require frequent visits to the doctors for infusions, etc.

    Here are some of challenges gene therapy currently faces:
    -insertional mutagenesis: the delivered gene inserts near an oncogene. The promoter of the inserted gene activates the nearby oncogene, which causes the patient to develop cancer.

    -delivery to a target location: it's often difficult to target a specific organ. We can dose the entire body, or we can inject directly into the organ. The long term goal would be to be able to inject via IV, and the vector would target the desired organ.

    -immune system: the most common vector used is a virus. The body's natural defenses cannot differentiate between our developed helpful viruses and harmful viruses. A immune response is generally invoked.

    -The ability of the body to retain the effects. If cells "infected" by the helpful virus are destroyed by the immune system, will the effect of the therapy make a difference? How long is the deliver gene "functional"? This needs to be improved - perhaps by targeting stem cells.


    Finally, in response to the comment above regarding passing the effects to children. In theory it is possible to alter the germ line. However, this is against regulations by the FDA and NIH. Currently, the only trial I know of that saw the gene delivered to a germ cell is in a trial treating hemophilia. the trial was postponed to investigate why this occurred.
  • bischero

    Posts: 847

    Oct 20, 2012 12:12 AM GMT
    Where do we draw the line? What does it mean to be human? Will we become a species that is less than human?


    I say let evolution do its work on its own. Sometimes, when mankind interferes with nature, things go wrong. This could go terribly wrong.
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    Oct 20, 2012 12:27 AM GMT
    Hopefully they'll weed out everyone with an IQ of less than 120. icon_twisted.gif
  • Posted by a hidden member.
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    Oct 20, 2012 12:47 AM GMT
    Yes please, I'll take a pair of retractable wings, a prehensile tail, and a glow in the dark layer of fur.

    How much?
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    Oct 20, 2012 12:49 AM GMT
    Stuttershock saidYes please, I'll take a pair of retractable wings, a prehensile tail, and a glow in the dark layer of fur.

    How much?
    $2.1 mil
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    Oct 20, 2012 12:57 AM GMT
    paulflexes said
    Stuttershock saidYes please, I'll take a pair of retractable wings, a prehensile tail, and a glow in the dark layer of fur.

    How much?
    $2.1 mil


    From all the money I will save on air travel and winter clothing, it practically pays for itself!
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    Oct 20, 2012 1:05 AM GMT
    Stuttershock said
    paulflexes said
    Stuttershock saidYes please, I'll take a pair of retractable wings, a prehensile tail, and a glow in the dark layer of fur.

    How much?
    $2.1 mil


    From all the money I will save on air travel and winter clothing, it practically pays for itself!
    It takes birds several weeks to fly the same distance that airlines fly in a few hours. Are you sure it'll save on air travel? icon_wink.gif
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    Oct 20, 2012 1:18 AM GMT
    paulflexes said
    Stuttershock said
    paulflexes said
    Stuttershock saidYes please, I'll take a pair of retractable wings, a prehensile tail, and a glow in the dark layer of fur.

    How much?
    $2.1 mil


    From all the money I will save on air travel and winter clothing, it practically pays for itself!
    It takes birds several weeks to fly the same distance that airlines fly in a few hours. Are you sure it'll save on air travel? icon_wink.gif


    That's true, and I would also have to fly in formation to save energy. I wonder if Vladimir Putin is available to lead a migration.
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    Oct 20, 2012 1:21 AM GMT
    If genetically altering human DNA becomes a normal medical procedure, then all that we know now, all our social laws will be re-written. Case and point. If a human being can gain genetic enhancements to become per say the strongest swimmer, or fastest runner. Chances are there will not be room for documented achievements of individuals with such abilities who did not gain them through genetic manipulation. There is also the fact that with such added modifications, our society will enter a stage by which there will develop a social hierarchy, one that will no doubt take advantage of those who are just "normal humans". Our human history is filled with such instances. And it surprises me that we never learn from them. Hitler made it his prerogative to remove what he felt was a sub-species of humanity. African Kings sold their own into slavery who they believed were a sub caste of their culture. The same goes for the now far extinct Albino race. Yes there was a ethnic group of Albinos living in africa but they were wiped out through genocide. With every progress made in Humanity, there is a price to pay. I hope this never happens.
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    Oct 20, 2012 1:29 AM GMT
    Stuttershock said
    paulflexes said
    Stuttershock said
    paulflexes said
    Stuttershock saidYes please, I'll take a pair of retractable wings, a prehensile tail, and a glow in the dark layer of fur.

    How much?
    $2.1 mil


    From all the money I will save on air travel and winter clothing, it practically pays for itself!
    It takes birds several weeks to fly the same distance that airlines fly in a few hours. Are you sure it'll save on air travel? icon_wink.gif


    That's true, and I would also have to fly in formation to save energy. I wonder if Vladimir Putin is available to lead a migration.
    Birds don't fly in formation to save energy. In fact, they stay out of the "wake turbulence" created by the bird(s) in front of them because it requires more energy. They only fly in formation because it's easier to keep up with each other.

    nbc_the_more_you_know1-300x197.jpg
  • Vaughn

    Posts: 1880

    Oct 20, 2012 1:37 AM GMT
    The've already started modifying humans. There was a deaf couple who had thier child modified for deafness.
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    Oct 20, 2012 1:51 AM GMT
    If you want to know more in detail about where this is going, and just the future of technology I HIGHLY suggest reading "The Sigularity Is Near :When Humans Transcend Biology" by When Humans Transcend Biology by Ray Kurzweil. it is very backed up hypothesis of the next 50 years.