Oct 21, 2012 12:50 PM GMT
A drug made from a plant known as “thunder god vine,” or lei gong teng, that has been used in traditional Chinese medicine, wiped out pancreatic tumors in mice, researchers said, and may soon be tested in humans.
Mice treated with the compound showed no signs of tumors after 40 days or after discontinuing the treatment, according to researchers at the University of Minnesota’s Masonic Cancer Center. The research, funded by the university and the National Institutes of Health. was published today in the journal Science Translational Medicine.
“This drug is just unbelievably potent in killing tumor cells,” said Ashok Saluja, vice chairman of research at the center and the study’s leader, said in a telephone interview. “You could see that every day you looked at those mice, the tumor was decreasing and decreasing, and then just gone.”
The plant, also known as Tripterygium wilfordii, contains triptolide, which earlier studies have shown can cause cancer cells to die. In traditional Chinese medicine, the plant is used as a treatment for rheumatoid arthritis. While the researchers hope to start human trials in six months, Saluja said it’s still a long leap from mice to people.
“Does that mean it will definitely work in humans?” he said. “We can definitely not say that.”
The results pave the way for clinical trials in patients with pancreatic cancer, one of the most lethal malignancies, the researchers said in the study. About 44,000 new cases of the disease are diagnosed each year in the U.S., according to the U.S. Centers for Disease Control and Prevention in Atlanta. Only about 20 percent of patients survive a year after diagnosis, Saluja said.