Resveratol and testosterone: is there a link?

  • Zinc

    Posts: 197

    Feb 19, 2013 1:14 AM GMT
    I keep hearing about resveratol, one of the substances found in grapes and red wine. Usually it is talked about as an anti-oxidant, but I have also heard that it can increase serum testosterone. I found a study below that showed this for rabbits, but is there evidence it works in humans to the same effect?
    http://www.ncbi.nlm.nih.gov/pubmed/18277612
  • Zinc

    Posts: 197

    Feb 19, 2013 1:18 AM GMT
    Is there some gnome somewhere that decides which topics get posted to the main page? This one seems to be getting buried. icon_confused.gif
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    Feb 19, 2013 3:26 AM GMT
    I hate the fact publicly funded research is not accessible to public !

    The abstract speak about a clear effect, but without access to the full text of the study it's difficult to asses anything.

    The percentage given are meaningless without the number of rabbit studied, information on the reference group and the protocol.
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    Feb 19, 2013 3:30 AM GMT
    Do rabbits really need help with having sex? icon_confused.gif
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    Feb 19, 2013 3:33 AM GMT
    Is this the same rumor that says licorice lowers testosterone??? But it tastes so GOOD!!!!
  • LuckyGuyKC

    Posts: 2080

    Feb 19, 2013 3:58 AM GMT
    MMMMM.... need red wine nightly!
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    Feb 19, 2013 4:02 AM GMT
    I read about this a while ago and apparently the resveratrol has a really low absorption rate to the point you'd have to take bucket loads for it to be effective. There are studies that have been done on humans though and found that it also works in in us.
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    Feb 19, 2013 4:05 AM GMT
    Resveratrol, being a flavonoid, doesn't seem to have any direct effect on hormonal production.
    Until I see better studies, I'll stay skeptical.

    Until then, I will enjoy a glass of red wine for res and intense workout for test release.
  • Zinc

    Posts: 197

    Feb 19, 2013 4:18 AM GMT
    minox saidI hate the fact publicly funded research is not accessible to public !

    The abstract speak about a clear effect, but without access to the full text of the study it's difficult to asses anything.

    The percentage given are meaningless without the number of rabbit studied, information on the reference group and the protocol.


    It's a South Korean study, I wonder if that has anything to do with it? I know studies funded by NIH must post their work for everyone.
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    Feb 19, 2013 4:54 AM GMT
    uoft23 saidI read about this a while ago and apparently the resveratrol has a really low absorption rate to the point you'd have to take bucket loads for it to be effective. There are studies that have been done on humans though and found that it also works in in us.


    That is the single biggest caveat to any study I read on resveratrol; that combined with the fact that red wine itself doesn't have too high a concentration of the stuff. You'd have to get pretty drunk on red wine every day to ingest the doses given to test subjects in resveratrol studies. (Do you have a link to the study/studies?)

    Resveratrol has been characterized as an inhibitor of the enzyme aromatase - the enzyme that turns testosterone into estrogen. (http://www.ncbi.nlm.nih.gov/pubmed/16611627) And studies have shown that elderly men that went on an aromatase inhibitor regimen (anastrozole) had an increase in serum testosterone. So I guess that's proof of principle that a regimen of resveratrol could plausibly lead to an increase in serum testosterone.

    Although that aromatase inhibition study reported the IC50 at 25uM which is pretty high - meaning that resveratrol isn't that potent when you consider that most ingested pharmaceuticals have an IC50 in the nM range (100-1000x more potent than resveratrol). And that's not even considering the molecule's pharmacokinetics, which is a whole 'nother kettle of fish.

    Edit: Forgot to include the link to the elderly men study http://www.ncbi.nlm.nih.gov/pubmed/15001605
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    Feb 19, 2013 5:18 AM GMT
    ART_DECO saidDo rabbits really need help with having sex? icon_confused.gif


    RIGHT!!!! LMAO!!! Get Velvet Deer Antler powder or serum instead, way better results! icon_neutral.gif
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    Feb 19, 2013 5:42 AM GMT
    Chuckles777 said
    ART_DECO saidDo rabbits really need help with having sex? icon_confused.gif

    RIGHT!!!! LMAO!!! Get Velvet Deer Antler powder or serum instead, way better results! icon_neutral.gif

    Actually the subject has interested me because I was diagnosed with low testosterone, typical for my age. I was put on topical Testim, which had virtually no effect, and certainly not worth the high cost and inconvenience. (And now a moot point, at least for the time being, since we want my testosterone to be lower following my prostate cancer treatment last year)

    But I did think I saw a cause & effect of more natural activities that could raise my testosterone to low-normal levels. They included exercise, sexual activity, and stimulation from gay porn. I even think just living & sleeping with my husband boosts the hormone some small amount.
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    Feb 19, 2013 6:25 AM GMT
    Reservatol is generally for heart & lowering cholestrol

    testosterone is for making a man very masculine same goes for female who take it for making them manly , ie masculine lesbians

    it gives u a nice beard & a very high sexual drive, but its always said the external testasterone gives cancer & destroys the liver & kidney , almost all athletes & wrestlers die of cancer & organ failures
    reason , High testasterone

    well lance Armstrong is one good reason , he got cancer too , thank god he's safe now
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    Feb 19, 2013 7:35 AM GMT
    I wouldn't mind a natural boast or at least a way to more quickly repair muscles. Does Creatine or anything out there LEGALLY speaking help with this?
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    Feb 19, 2013 9:57 AM GMT
    creatine increases the blood flow in the muscles & give a preliminary protein supplement
  • Zinc

    Posts: 197

    Mar 10, 2013 11:28 PM GMT
    Interesting article on resveratol analogues being developed.

    New drug being developed using compound found in red wine 'could help humans live until they are 150'

    Read more: http://www.dailymail.co.uk/health/article-2291254/New-drug-developed-using-compound-red-wine-help-humans-live-150.html#ixzz2NBNWiBx0
    Follow us: @MailOnline on Twitter | DailyMail on Facebook

    http://www.dailymail.co.uk/health/article-2291254/New-drug-developed-using-compound-red-wine-help-humans-live-150.html
  • Teth1

    Posts: 39

    Mar 12, 2013 6:31 PM GMT
    If it has an effect on rabbits safe to say to an extent that something similar would be found for people. But dang...

    http://www.ncbi.nlm.nih.gov/pubmed/18277612resveratrol did elicit an increase in blood testosterone concentration....by 51.6%


    That's pretty nuts.

    erm...continuing.

    Hard to believe that that much of an effect would be seen in rabbits from resveratol. I'd bet a similar effect would be had for people but not by 50%.

    Pomegranate juice is easy to buy and has been shown to raise testosterone as well.

    http://www.askmen.com/dating/dating-news/pomegranate-juice.htmlThe subjects saw an increase in testosterone ranging between 16% and 30% and some other useful side effects were noticed, too. Both sexes saw a drop in blood pressure and an increase in positivity as negative emotions decreased.
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    Mar 12, 2013 6:40 PM GMT
    Last I read about testosterone, anything that you perceive as good for you, be it looking at hot men, getting their attention, having sex, working out, taking something that is good for you, getting a good night sleep, etc will all temporarily increase testosterone. Losing a game you are competitive at, being rejected and not being able to cope with it and be resilient, are all associated with reduced levels. So those studies can all be confounded because psychological changes (neuro) influences the endocrine system at the pituitary gland, which releases hormones that act on your testes. Plus, the body operates in negative feedback loops, so if you get too much good for a while, expect for a crash later--for example, if you exercise enough, you'll get testosterone elevation temporarily and less later...

    From a dietary perspective, it isn't possible to get a significant amount of resveratrol from wine, grapes, or peanuts. You would have to get cirrhosis first and alcohol poisoning, which obviously aren't healthy. Last I did the calculation, it was like 78-150 bottles of red wine...

    Maybe supplementation? Even so, supplements aren't pure themselves either.
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    Mar 14, 2013 6:30 AM GMT
    Zeriel saidcreatine increases the blood flow in the muscles & give a preliminary protein supplement


    Creatine has nothing to do with protein. Doh. It's an ATP catalyst. It is not nitric oxide. I'm afraid you're wrong in both proclamations.

    Creatine (/ˈkriːətiːn/ or /ˈkriːətən/ or /ˈkriːətaɪn/[1][2]) is a nitrogenous organic acid that occurs naturally in vertebrates and helps to supply energy to all cells in the body, primarily muscle. This is achieved by increasing the formation of adenosine triphosphate (ATP). Creatine was identified in 1832 when Michel Eugène Chevreul discovered it as a component of skeletal muscle, which he later named after the Greek word for meat, κρέας (kreas). In solution, creatine is in equilibrium with creatinine.[3]