James Gandolfini was known by billions, and it's a shame that he never was on top of his condition. He was only 51.
For those that don't know: about 10% of all myocardial infarctions (heart attacks) happen to people less than 45 years of age, and that number is increasing.
Also, the highest rate of sudden death from MI results in long distance runners. Cardiologists aren't sure why, but, suspect ongoing trauma to the heart is a factor.
Genetics, diet, and exercise (or lack there of it), companionship, race, and personality type, all are factors in heart disease.
Keep your blood pressure with the low to low high range is very important, no matter what your other risk factors, to keeping heart disease from taking your life.
Just about everyone has some level of heart disease, but, for some, despite the best of risk factors, genes win.
You MUST monitor your blood pressure, and not eat fried, salty, saturated fat junk. Even, then, you can have a perfect lipid panel and still see progression of heart disease. The only way to know is to know your BP, and do a stress test (on your own, or in a clinical setting) as well as your blood sugar, and lipid panel. You need your poly and mono fats...and it's important to have fat in your diet.
It's pretty well known these days that TMAO is found in higher levels in cardiac patients.
Red meat has lots of TMAO, and other food that don't provide it are likely better choices for good, long term, wellness. Beef is something best left outside your home, and only eaten occasionally.
Clearly, alcohol in high amounts is a major risk factor. So are rec drugs.
Some folks, though, can be be fit, have a good diet, and genetics nails them.
I've seen horrible numbers on young men in their late teens and 20's with rapid heart rate, high bp, and terrible blood profiles, because their diets suck, and they use pre-workout stuff (which can be very hard on your cv system.)