I typed up a deep heartfelt response with tons of facts and my browser crashed so while i write up my response i will post this:
50 DISASTERS OF ANIMAL TESTING
1. Benzene was not withdrawn from use as an industrial chemical despite clinical and epidemological evidence that exposure caused leukemia in humans, because manufacturer-supported tests failed to reproduce leukemia in mice.
2. Smoking was thought to be non-carcinogenic because smoking-related cancer is difficult to reproduce in lab animals. Consequently many continued to smoke and to die from cancer.
3. Animal experiments on rats, hamsters, guinea pigs, mice, monkeys, and baboons revealed no link between glass fibers and cancer. Not until 1991, due to human studies, did OSHA label it carcinogenic.
4. Though arsenic was a known human carcinogen for decades, scientists still found little evidence in animals to support the conclusion as late as 1977. This was the accepted view until it was eventually possible to produce in animals.
5. Many humans continued to be exposed to asbestos and die because scientists could not reproduce the cancer in laboratory animals.
6. Pacemakers and heart valves were delayed in development because of physiological differences between animals on which they were designed and humans for whom they were intended.
7. Animal models of heart disease failed to show that a high cholesterol/high fat diet increases the risk of coronary artery disease. Instead of changing their eating habits to prevent the disease, people continued their lifestyles with a false sense of security.
8. Patients received medications that were harmful and/or ineffective due to animal models of stroke.
9. Animal studies predicted that beta-blockers would not lower blood pressure. This withheld their development. Even animal experimenters admitted the failure of animal models of hypertension in this regard, but in the meantime, there were thousands more stroke victims.
Used with kind permission
of The Covance Campaign
10. Surgeons thought they had perfected radial keratotomy, surgery performed to enable better vision without glasses, on rabbits, but the procedure blinded the first human patients (The rabbit cornea is able to regenerate on the underside, whereas the human cornea can only regenerate on the surface). Surgery is now performed only on the surface.
11. Combined heart lung transplants were supposedly 'perfected' on animals, but the first 3 human patients all died within 23 days. Of the 28 patients operated on between 1981 and 1985, 8 died peri-operatively, and 10 developed obliterative bronchiolitis, a lung complication that the dogs on whom experiments had been conducted did not develop. Of those 10 humans who developed obliterative bronchiolitis, 4 died and 3 never breathed again without the aid of a respirator. Obliterative bronchiolitis turned out to be the most important risk of the operation.
12. Cyclosporin A inhibits organ rejection, and its development was a watershed in the success of transplant operations. Had human evidence not overwhelmed unpromising evidence from animals, it would never have been released.
13. Animal experiments failed to predict the kidney toxicity of the general anesthetic methoxyflurane. Many people lost all kidney function.
14. Animal experiments delayed the use of muscle relaxants during general anesthesia.
15. Research on animals failed to reveal bacteria as a cause of ulcers and delayed treating ulcers with antibiotics.
16. More than half of the 198 new medications released between 1976 and 1985 were either withdrawn or relabeled secondary to severe unpredicted side effects. These side effects included complications such as lethal dysrhythmias, heart attacks, kidney failure, seizures, respiratory arrest, liver failure, and stroke, among others.
17. Flosint, an arthritis medication, was tested on rats, monkeys and dogs; all tolerated the medication well. However, in humans it caused deaths.
18. Zelmid, an antidepressant, was tested on rats and dogs without incident, but it caused severe neurological problems in humans.
19. Nomifensine, another antidepressant, was linked to kidney and liver failure, anemia, and death in humans. And yet animal testing had indicated that it could be used without side-effects occurring.
20. Amrinone, a medication used for heart failure, was tested on numerous animals and was released without any trepidation. But humans developed thrombocytopenia, a lack of the type of blood cells that are needed for clotting.
21. Fialuridine, an antiviral medication, caused liver damage in 7 out of 15 people. 5 eventually died and 2 more needed liver transplants. And yet it had worked well in woodchucks.
22. Clioquinol, an antidiarrheal, passed tests in rats, cats, dogs and rabbits. But it had to be withdrawn all over the world in 1982 after it was found to cause blindness and paralysis in humans.
23. Eraldin, a medication for heart disease, caused deaths and blindness in humans despite the fact that no untoward effects could be shown in animals. When introduced, scientists said it noted for the thoroughness of the toxicity studies on animals. Afterwards, scientists were unable to reproduce these results in animals.
24. Opren, an arthritis medication, killed 61 people. Over 3500 cases of severe reactions have been documented. Opren had been tested on monkeys and other animals without problems.
25. Zomax, another arthritis drug, was responsible for the death of 14 people and causing suffering to many more.
26. The dose of isoproterenol, a medication used to treat asthma, was calculated in animals. Unfortunately, it was much too toxic for humans. 3500 asthmatics died in Great Britain alone due to overdose. It is still difficult to reproduce these results in animals.
27. Methysergide, a medication used to treat headaches, led to retroperitoneal fibrosis, or severe scarring of the heart, kidneys, and blood vessels in the abdomen. Scientists have been unable to reproduce this in animals.
28. Suprofen, an arthritis drug, was withdrawn from the market when patients suffered kidney toxicity. Prior to its release researchers had this to say about the animal tests: '...excellent safety profile. No...cardiac, renal, or CNS [central nervous system] effects in any species'.
29. Surgam, another arthritis drug, was designed to have a stomach protection factor that would prevent stomach ulcers, a common side effect of many arthritis drugs. Although promising in lab animal tests, ulcers occurred in human trials.
30. Selacryn, a diuretic, was thoroughly tested on animals, but it was withdrawn in 1979 after 24 people died from drug induced liver failure.
31. Perhexiline, a heart medication, was withdrawn when it produced liver failure which had not been predicted by animal testing. Even when the particular type of liver failure was known, it could not be induced in animals. 32. Domperidone, designed as a treatment for nausea and vomiting, made human hearts beat irregularly and had to be withdrawn. Scientists were unable to reproduce this in dogs even with 70 times the normal dose.
33. Mitoxantrone, a treatment for cancer produced heart failure in humans. It was extensively tested on dogs, which did not manifest this effect.
34. Carbenoxalone was supposed to prevent formation of gastric ulcers but caused people to retain water to the point of heart failure. After vivisectors knew what it did to humans they tested it on rats, mice, monkeys, rabbits, but could not reproducing this effect.
35. Clindamycin, an antibiotic, causes a bowel condition called pseudomenbraneous colitis. And yet it was tested in rats and dogs every day for a year; moreover, they were able to tolerate doses ten times greater than h