RESEARCH ON HIV INFECTION

  • alexpiwi

    Posts: 3

    Sep 16, 2007 6:41 AM GMT
    AIDS, first report in 1981, has killed more than 25 million people. Human immunodeficiency virus (HIV) is associated to cause AIDS. HIV infects human cells CD4+; those are T cells, macrophages and dendritic cells, which form part of the immune system. As an obligate intracellular parasite HIV is a formidable target for drug development. Antiviral drugs for HIV already have been design. These drugs obstruct in some point the viral life cycle. However unacceptable host cell toxicity may occur.

    The cellular processes know as RiboNucleic Acids Interference (RNAi) is the hottest topic in science. Why? Imagine a disease gene function can be switching off by target it in a specific manner. That’s the promise of RNAi. Since discovery of RNAi pathway (1998) many diseases associated to genes have been studies. Reports show effective protection against Dengue virus, Herpes simplex virus, hepatitis B and C virus, Influenza A, Parainfluenza and Respiratory syncytial virus in animal models. RNAi promises to have an important impact on AIDS research. Although the therapeutic application of RNAi in HIV infection faces many obstacles. Advances are being made. RNAi can be also used to understanding the interplay between HIV and its host, and indicate new cellular targets for drug design. In the future, technical challenges associated with RNAi tools should be controlled and then a non-toxic and highly effective treatment for HIV infection will be real. Research on HIV infection
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    Sep 16, 2007 10:55 PM GMT
    Thank you for this posting...its so important that we stay current on the topic...but more formidable in my mind, is addressing the issue of infected gay men knowingly engaging in unprotected sex and not notifying their partners.

    its illegal to do so in the state of Georgia and one man is now in prison here for infecting someone.

    I have two friends who recently became aware of their positive status and both got it from men who knew they were positive and told them they were negative...these infected men felt they werent at risk to others because they have an "undetectable" level of HIV...turns out both had viral loads of over 5,000....hardly undetectable when the CDC classifies "undetectable" as less than 50.

    One is about to be charged with a felony and I for one hope he gets sentenced to a prison term.

    Its criminal and it must be stopped.

    Everyone...get tested no less than every six months and lets stop the spread of this disease...its in our control if we could just get control of the men in our community who are spreading it and dont care about the affect they are having on others...
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    Sep 16, 2007 11:20 PM GMT
    alexipiwi,
    i'd appreciate a source for your info. Thanks...
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    Sep 16, 2007 11:49 PM GMT
    MJA: Did these guys have unprotected, receptive anal sex with the infected guys?
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    Sep 17, 2007 12:49 AM GMT
    I read a report on a inconclusive study done years ago regarding people exposed to HIV the same as others that developed the disease. I think it is odd that this line of research has not been pursued.
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    Sep 17, 2007 1:39 AM GMT
    ObsceneWish, you miss the point....AGAIN...these men were deceived in the worst possible way by men they trusted...they werent hook ups...they were dating for months...and the men who had HIV... LIED to them....deliberately deceiving them and giving them a false sense of security and they knowingly inserted their penis in my friends without protection...with no regard for their well being...I dont know the rest of the details...and its not necessary...

    Men like these have to be stopped and its through their incarceration that we can hopefully get the word out that there are consequences to this behavior....and it will STOP ans the spread of the disease will stop.
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    Sep 17, 2007 1:47 AM GMT
    I agree with you that it's pretty crappy to do that to someone. But one thing I've learned from the gay community is it doesn't matter how long I've been going out with you or even if we're married, condoms will always be used.
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    Sep 17, 2007 2:19 AM GMT
    Uh, how did I miss the point AGAIN? Because I asked a secondary question?

    My partner is an epidemiologist at CDC who designs HIV intervention studies, including the first for gay men. Transmission in those claiming to be "undetectable" is controversial, since viral load for blood and semen are different measurements and peak at different times.

    I was simply interested in the method of transmission since there is interesting, counter-intuitive epidemiological data about the contagious status of men who have passed the initial period of infection.

    I don't think I missed the point. I think your point is self-evident, but it raises other questions that interest me.

    Alex: I asked my partner about the RNAi study and he was interested in your citation, too. Thanks for providing it.
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    Mar 30, 2008 11:16 PM GMT
    I remember reading about some Doctor in Brazil who figured out that some cell called Dendrites usually fail to activate their part of the body's immune responce and so allow hiv to flourish but discovered that some people have dendrites that activate and irradicate the hiv. Supposedly he has a method of taking dendrite cells out of an infected person, activating it, reintroducing it into the body and the activated dendrites activate the the others in the body. It's kind of like a custom vaccine for the hiv strain that an individual has. Have any of you heard of this? I read this like two years ago and was encouraged. I've heard nothing of it since.

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    Apr 05, 2008 10:26 AM GMT
    John43620 saidI remember reading about some Doctor in Brazil who figured out that some cell called Dendrites usually fail to activate their part of the body's immune responce and so allow hiv to flourish but discovered that some people have dendrites that activate and irradicate the hiv. Supposedly he has a method of taking dendrite cells out of an infected person, activating it, reintroducing it into the body and the activated dendrites activate the the others in the body. It's kind of like a custom vaccine for the hiv strain that an individual has. Have any of you heard of this? I read this like two years ago and was encouraged. I've heard nothing of it since.



    You mean Dendritic cells.

    Dendrites are the branched 'head' of our neurons (brain cells), while Dendritic cells are like... command centers of our immune systems. They store all 'knowledge' for the body's defenses (i.e. which are hostile and to be attacked, which are body cells and should be left alone, etc.).
  • joeindallas

    Posts: 484

    Apr 07, 2008 9:33 PM GMT
    Hidden Member I was shocked to hear two guys talking at a Starbucks, about a Daddy and how good he was at a Gift Giving Party. For those who do not know the "GIFT" they are talking about is HIV. Just look and see how many people on this site refuses to comment on HIV status. I was in an accident in August of 2007 I was shocked that the Hospital had Green and Red dots on the name plates at the door.

    Memeber I agree people should be more careful a guy could look like Mister O and still be a carrier. No I do not mean Jay is just setting the image
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    Apr 07, 2008 9:41 PM GMT
    joeindallas saidI was in an accident in August of 2007 I was shocked that the Hospital had Green and Red dots on the name plates at the door.



    I do not know what this means.
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    Apr 08, 2008 9:40 PM GMT
    Must have been dendritic cells then, whatever they are called, has anyone else heard of this procedure?