The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties
L. R. Chadwick, G. F. Pauli, and N. R. Farnsworth
UIC/NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
"Hops have been shown to contain one of the most potent in vitro estrogenic substance known from the plant kingdom, (±)-8-prenylnaringenin (Kitaoka et al., 1998; Milligan et al., 1999). They are mentioned repeatedly in popular texts to have sedative-like activity (Blumenthal, 2000; Fluckiger and Hanbury, 1879; Gathercoal and Wirth, 1936; Schulz et al., 2001; Youngken, 1950). Thus, given the history of long-term and present use in humans with no significant adverse effects, an initial hypothesis is that hops are safe."
Phytomedicine. Author manuscript; available in PMC 2007 April 17.
Published in final edited form as:
Phytomedicine. 2006 January; 13(1-2): 119–131.
Published online 2005 July 1. doi: 10.1016/j.phymed.2004.07.006.
While the author states that for various reasons good clinical trials have not been done to investigate the estrogenic effect of hops on humans, when you look at the overall body of work on hops and the large body of anecdotal evidence going back several hundred years, there is more than reasonable suspicion that substances from hops are indeed estrogenic in the body.