A once every three-months HIV prevention method? Potentially.

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    Mar 04, 2014 7:55 PM GMT
    https://news.yahoo.com/studies-show-big-promise-hiv-prevention-drug-174148333--finance.html

    An injection every three months - at the same time as your regular HIV test. Next-best-thing to a vaccine? Too early to tell. And no word yet on whether anybody would be able to afford it.

    It's frustrating that the story doesn't actually say what the stuff is.

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    Mar 04, 2014 9:37 PM GMT
    THC. icon_twisted.gif
  • thadjock

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    Mar 04, 2014 11:37 PM GMT
    the FDA has already approved an HIV preventative drug Truvada if you're insane enough to use it.

    it's super pricey, and i'm sure there are side effects but it's on the market. side effects here:

    http://www.truvada.com/

    isn't it easier to just not whore around?
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    Mar 04, 2014 11:54 PM GMT
    It turns out nobody is using Truvada - I think in the other thread there was some reference to data showing only about 700 people worldwide have prescriptions for PreP use. For whatever reason, the manufacturer is not making any effort to promote it or make it more widely available. For most people, the risks may outweigh the benefit.

    The big difference with this stuff (whatever it is) if it works, is that one dose every three months would be a lot easier to get compliance with than dosing every day. We'll leave the number-crunching up to the epidemiologists, but it might theoretically be possible to begin approaching an eradication program, even in the absence of a vaccine.

    But that's way in the future. If it costs $K per dose, or makes your teeth fall out, forget it.
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    Mar 04, 2014 11:57 PM GMT
    I some ways, I have more compassion for the monkeys in the study
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    Mar 05, 2014 12:01 AM GMT
    True... they didn't even get to have sex. Just injections of HIV twice a week.
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    Mar 05, 2014 12:35 AM GMT
    Well, if anybody cares, it is this stuff:
    230px-GSK744.svg.png
    http://en.wikipedia.org/wiki/GSK744

    Similar to "dolutegravir" which is already in use, and is not without side effects. For one thing, some people are allergic to it.
    250px-Dolutegravir.svg.png
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    Mar 05, 2014 12:40 AM GMT
    mindgarden saidWell, if anybody cares, it is this stuff:
    230px-GSK744.svg.png
    http://en.wikipedia.org/wiki/GSK744

    Similar to "dolutegravir" which is already in use, and is not without side effects. For one thing, some people are allergic to it.
    250px-Dolutegravir.svg.png


    all that Flourine is not a good sign
  • thadjock

    Posts: 2183

    Mar 05, 2014 2:25 AM GMT
    somersault said

    all that Flourine is not a good sign


    yeah you gotta drop the Flourine, and a couple more tweaks, to reengineer it so it looks alot more like this:

    500px-Methamphetamine_leuckart_synthesis

    then you'll have a pharmaceutical the gay community can really get behind.

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    Mar 05, 2014 3:00 AM GMT
    mindgarden saidTrue... they didn't even get to have sex. Just injections of HIV twice a week.


    Well, it turns out that this isn't entirely true. In one of the three experiments, the HIV dose was inserted anally.
    Which means that somewhere, there is a lab assistant whose job description includes something like "monkey fucker."
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    Mar 05, 2014 3:08 AM GMT
    mindgarden said
    mindgarden saidTrue... they didn't even get to have sex. Just injections of HIV twice a week.


    Well, it turns out that this isn't entirely true. In one of the three experiments, the HIV dose was inserted anally.
    Which means that somewhere, there is a lab assistant whose job description includes something like "monkey fucker."


    wonderful, they should test this crap on convicted rapists and illegal aliens instead of innocent monkeys
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    Mar 05, 2014 4:28 AM GMT
    Too bad there's no Nuva ring or subcut device for men that can deliver ART drugs for years at a time. That would go a long way in preventing HIV transmission.
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    Mar 05, 2014 4:49 AM GMT
    panther2013 saidToo bad there's no Nuva ring or subcut device for men that can deliver ART drugs for years at a time. That would go a long way in preventing HIV transmission.


    This nooz story came out of a session at ICAAC. That's actually what some of the other papers in the session were about. These particular papers were actually testing a delayed-release form of the drug in injectable nanobeads. Which apparently last about three months. I find myself wondering exactly how big these injections would be, scaled up to human size. Even if it's delayed-release, it's still three-month's dose icon_eek.gif
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    Mar 05, 2014 5:36 AM GMT
    mindgarden said
    panther2013 saidToo bad there's no Nuva ring or subcut device for men that can deliver ART drugs for years at a time. That would go a long way in preventing HIV transmission.


    This nooz story came out of a session at ICAAC. That's actually what some of the other papers in the session were about. These particular papers were actually testing a delayed-release form of the drug in injectable nanobeads. Which apparently last about three months. I find myself wondering exactly how big these injections would be, scaled up to human size. Even if it's delayed-release, it's still three-month's dose icon_eek.gif


    Injecting preventative devices like for birth control is already a practice.

    This rod is injected into the inner bicep of a female and offers birth control dosage for 3 years.

    fivcijov.jpg

    It's about the size of a match and comes with a device to inject it. It's done with a local anesthetic to minimize the ouchy factor.
  • frogman89

    Posts: 418

    Mar 05, 2014 11:57 AM GMT
    I'll rather wait a few more years and play safe until there is a valid vaccine.
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    Mar 05, 2014 1:03 PM GMT
    frogman89 saidI'll rather wait a few more years and play safe until there is a valid vaccine.


    Even if we have a solid vaccine for the disease it could still take between 10 to 15 years of clinical trials and testing before such a vaccine can hit the market.

    A few more years might actually be a few more decades.
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    Mar 05, 2014 1:06 PM GMT
    thadjock saidthe FDA has already approved an HIV preventative drug Truvada if you're insane enough to use it.

    it's super pricey, and i'm sure there are side effects but it's on the market. side effects here:

    http://www.truvada.com/

    isn't it easier to just not whore around?

    And have safe sex. I lived with an HIV poz guy for years, and we had safe sex. I blew him and was the bottom, the most risky activity. We always used a latex condom, even for oral.

    I'm still negative, suggesting that safe sex works. And that HIV isn't the plague, if you know what you're doing. In fact, I think the risk of contracting certain other STDs is greater, even with safe sex, since some transmit much more easily than HIV.
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    Mar 05, 2014 1:20 PM GMT
    ART_DECO said
    thadjock saidthe FDA has already approved an HIV preventative drug Truvada if you're insane enough to use it.

    it's super pricey, and i'm sure there are side effects but it's on the market. side effects here:

    http://www.truvada.com/

    isn't it easier to just not whore around?

    And have safe sex. I lived with an HIV poz guy for years, and we had safe sex. I blew him and was the bottom, the most risky activity. We always used a condom, even for oral.

    I'm still negative, suggesting that safe sex works. And that HIV isn't the plague, if you know what you're doing. In fact, I think the risk of contracting certain other STDs is greater, even with safe sex, since some transmit much more easily than HIV.


    Safer sex is the way to go for now, and it can protect you.

    But there are certain high at-risk groups where condoms are just not an option. In South Africa I have worked with females who are disenfranchised by the men in their lives who forbid the use of condoms. Attempts to get females to take control of the power of prevention is difficult when men call the shots when it comes to condom use.

    Single females who do carry condoms in their purses are seen as 'loose' and ostracized by the community.

    If this product becomes available females can take it discreetly without having their partners or the community knowing about it.
  • frogman89

    Posts: 418

    Mar 05, 2014 1:21 PM GMT
    earthsearch said
    frogman89 saidI'll rather wait a few more years and play safe until there is a valid vaccine.


    Even if we have a solid vaccine for the disease it could still take between 10 to 15 years of clinical trials and testing before such a vaccine can hit the market.

    A few more years might actually be a few more decades.
    Possibly. But some vaccines are already in the 2nd phase of clinical approval. That means that there are people (humans! not animals!) who got the vaccine.
    It is a dilemma here, though. They got the vaccine, but the pharmaceutical company has to tell them to play safe. On the other hand, they can't find out if it works, if they don't have unprotected sex with hiv+ people.
    So you may be right. It will take a few more years than I suggested, until it can be evaluated properly. But we are on a good way!


    ART_DECO said
    thadjock saidthe FDA has already approved an HIV preventative drug Truvada if you're insane enough to use it.

    it's super pricey, and i'm sure there are side effects but it's on the market. side effects here:

    http://www.truvada.com/

    isn't it easier to just not whore around?

    And have safe sex. I lived with an HIV poz guy for years, and we had safe sex. I blew him and was the bottom, the most risky activity. We always used a latex condom, even for oral.

    I'm still negative, suggesting that safe sex works. And that HIV isn't the plague, if you know what you're doing. In fact, I think the risk of contracting certain other STDs is greater, even with safe sex, since some transmit much more easily than HIV.
    It is. Oh, it is.
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    Mar 05, 2014 1:32 PM GMT
    frogman89 said
    earthsearch said
    frogman89 saidI'll rather wait a few more years and play safe until there is a valid vaccine.


    Even if we have a solid vaccine for the disease it could still take between 10 to 15 years of clinical trials and testing before such a vaccine can hit the market.

    A few more years might actually be a few more decades.
    Possibly. But some vaccines are already in the 2nd phase of clinical approval. That means that there are people (humans! not animals!) who got the vaccine.
    It is a dilemma here, though. They got the vaccine, but the pharmaceutical company has to tell them to play safe. On the other hand, they can't find out if it works, if they don't have unprotected sex with hiv+ people.
    So you may be right. It will take a few more years than I suggested, until it can be evaluated properly. But we are on a good way!


    News about the 2nd phase of clinical approval is awesome.

    Yeah, that's the problem with research into prevention. I had to get a grant for testing of HIV prevention technology and the application necessitated the layout of ethical considerations for the trials. I stated in mine that the testing would only be done with monogamous couples. That still didn't help me to get definitive findings.

    I can't recall, but I think the prevention medium is distributed to a sample group and they are told to practice safe sex. Having safe sex is not something that happens in 100% of the cases afterwards and if one in the sample group gets infected whilst on the prevention medium it would then have to be investigated properly to see if (and how) the intervention failed, i.e., the vaccine failed.
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    Mar 05, 2014 4:02 PM GMT
    somersault said
    mindgarden said
    mindgarden saidTrue... they didn't even get to have sex. Just injections of HIV twice a week.


    Well, it turns out that this isn't entirely true. In one of the three experiments, the HIV dose was inserted anally.
    Which means that somewhere, there is a lab assistant whose job description includes something like "monkey fucker."


    wonderful, they should test this crap on convicted rapists and illegal aliens instead of innocent monkeys


    Illegal aliens are innocent.

    They need to do the testing on the people who manufacture it and their families. Then we will get some honesty.
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    Mar 29, 2014 2:53 PM GMT