Having lived and worked in Oregon for several years, I can tell you right now that it would be foolish for you to try to drive from SF all the way to Portland on 101 in November. No one who lives in Oregon would attempt it or recommend it.
On a good day in summer, it can take 4 or 5 hours to drive just from Florence to Cannon Beach (158 miles), west of Portland. At this time of year, coastal Oregon is subject to serious storms that bring lots of rain and even freezing rain.
The coastal highway can be iced up or even flooded at several points. While the coast is beautiful at any time of year, you would be wise to drive I-5 and then cut over, if you have to see the coast.
And you can still see a great deal of Oregon's beauty from the freeway. Corvallis is just off I-5... maybe a 15-minute drive. It's a cool little college town with a lot of bars and restaurants. I highly recommend it.
From I-5 in Oregon, you can reach the coast from several cities in the Willamette Valley. Each is positioned about 60 miles east. From Roseburg, you will hit Reedsport. From Eugene you will cut across the Cascades to Florence (but not recommended in winter, due to icy conditions in the passes).
From Corvallis you can reach Newport. The route is fairly level and the landscape wide open. I prefer this to the others.
And then return by the same route. Don't drive north on 101 because the only way to get to Portland from there is to take State Route 6 near Tillamook and that stretch of road can be icy and dangerous. There are some steep hill climbs and you're sharing the road with 18-wheelers and logging trucks.
You're talking about driving more than 600 miles. I recommend you divide it into two days of driving with an overnight stop in Medford, Oregon, not far north of the state line. There are plenty of motels and restaurants there. But I recommend making reservations ahead of time (now?) because a lot of people will be on the road for the holiday and the motels fill up fast. Best Western has an excellent reservation system and the prices are fairly reasonable.
I don't mean to rain on your parade but the weather in the Pacific Northwest at this time of year can change in as little as an hour. I also recommend you pack a sleeping bag and some bottled water and snacks. If you hit black ice and spin out and need road assistance, it's always better to have provisions on hand.
Yes, black ice is a serious hazard. Oregon doesn't get a lot of snow, but the highways, especially at night, can be icy and it's called "black ice" because at night it can look deceptively like a rainy sheen.
You also should know that there are several areas of construction along 101 on the Oregon Coast right now. Delays are common. I just checked the map and it looks like 5 or 6 areas that are affected. A good resource is:
I-5 between Eugene and Portland is highly congested. It's the principal route of commerce linking California and Washington. And be prepared for a major slowdown in Tualatin, about 20 miles south of the Portland area. It doesn't seem to matter what time of day it is.
Once you get to Portland, be sure to check out Powell's Book Store, one of the world's largest. It's in the city's historic Pearl District. A five-story building devoted to nothing but books. There's a cafe on the first floor, one of the reasons Powell's is a magnet for the hipster crowd.