HIV DRUGS IMPAIR BRAIN FUNCTION

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    Dec 02, 2015 1:35 AM GMT
    May allow longer life, but the downside is cognitive dissonance.


    https://www.yahoo.com/
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    Dec 02, 2015 2:28 AM GMT
    Yahoo impairs brain function.
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    Dec 02, 2015 4:17 AM GMT
    I deserve brownie points for making no comment whatsoever...
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    Dec 02, 2015 4:43 AM GMT
    Drugs in general have side effects. It's a risk-benefit analysis.
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    Dec 02, 2015 5:15 AM GMT
    mindgarden saidI deserve brownie points for making no comment whatsoever...
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    I'm just waiting for Timm to show up

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    Dec 02, 2015 10:16 PM GMT
    Please post a full link. I'm interested in learning more about the connection. I've also read the virus itself is thought to cause some neurological damage. Interesting read here:

    http://www.aidsbeacon.com/news/2012/02/29/hiv-aids-infection-increases-risk-of-brain-shrinkage/

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    Dec 02, 2015 11:35 PM GMT
    MuchMoreThanMuscle said
    CODY4U saidPlease post a full link. I'm interested in learning more about the connection. I've also read the virus itself is thought to cause some neurological damage. Interesting read here:

    http://www.aidsbeacon.com/news/2012/02/29/hiv-aids-infection-increases-risk-of-brain-shrinkage/



    That could possibly be a concern. At this point, I personally know a lot of HIV+ people varying from early twenties to people in their sixties and beyond. People taking their meds to sustain undetectable levels appear to be living healthy lives.

    Personally, I have witnessed people with bipolarism to have some of the most severe cerebral degradation and cognitive decline. Autopsies performed on people with untreated bipolar disorder have brains that literally resemble Swiss cheese. The sheathing that covers the cerebral dendrites literally breaks down. So imagine the back of your entertainment center where all the loose wires of your tv, blu ray players, etc. are losing their protective coating and the electrical signals start to cross one another. That's basically bipolar disorder in a nutshell. Thankfully, strict adherence to medication can prevent this from happening.

    I guess the worse case scenario would be to have untreated bipolar disorder and HIV. I had a (platonic) roommate like this years ago. He was extremely difficult to live with. I didn't last more than three months with him.


    Very interesting! This article says the virus can do quite a doozy on its own, so I'm sure bipolar coupled with HIV could do a double doozy on the brain. A friend of an acquaintance has the virus and is on meds and is supposedly undetectable, but I noticed that he repeats himself quite a bit. It seems like he has some memory issues already. He's in his early 40's, but he's had the virus since the mid 90's. The article mentions that aging with virus may be a factor. Sadly, it seems drug therapies can't prevent much of the deterioration. Though I guess the choice between memory loss or death is really a no-brainer (no pun intended).
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    Dec 03, 2015 10:48 PM GMT
    Well it is interesting! I've been a part of the HNRC (HIV Neurological research Center) for many MANY years. I am part of the original study in the 90s. My dossier looks like a phone book.

    http://link.springer.com/article/10.1007/s13365-010-0009-y/fulltext.html

    If you look at the table, there is a much higher incidence of drug abuse, notably Meth and Opioids in long term (chronic) HIV samples. Also among them are a higher degree of depression. Neither of which has been an issue for me.

    Not sure if it matters but my CDD4 is 2x of chronic mean. 1330 vs 570.


    Looking at the Mean Deficit Score (lower is better) there is a marked difference in cognitive and motor skills. Negative, newly infected and chronic HIV = a stair step pattern from best to worse. There are two odd stats: Motor skills of newly infected are better than Neg or chronic, and verbal is near chronic and Negative, lowest for newly infected.

    If you include the error bars there is a lot MORE overlap.

    You don't have to be a rocket scientist to assume that an aging former Meth-head with depression, alcoholic who had years of HIV infection, then later becoming Undetectable would still have issues!

    Just look a the 'Major Depression" (lifetime and current) of chronic HIV. That alone could be enough to skew results. Together with drug abuse the findings are not at all surprising. If factoring in AGE (this study does not) the results would be more obvious.

    Nor can anyone infer that ALL Negative people's results are superior to ALL HIV people. There is cognitive impairment in the negative study too, even with 0 opioid use.

    The link Blondizgd gave was a general yahoo link. If it does say cognitive dissonance, I've seen plenty of that on RJ. It seems a majority here can not comprehend Treatment as Prevention, cognitive dissonance: the state of having inconsistent thoughts, beliefs, or attitudes, especially as relating to behavioral decisions and attitude change.


    "For example, the hackneyed spirit of “it’s not a death sentence” logically supposes that HIV is a dangerous, spooky thing that somehow just happens by someone’s life. And while the notion itself is quaint, it creates logical and cognitive dissonance."

    http://www.hivplusmag.com/treatment/daily-dose/2013/12/27/big-disconnect-around-hiv-prevention