For years, I worked for employers who expected me to be in the lab or office 16-20 hours a day, 7 days a week. Basically, I was living at work, except I had to pay a bunch of money to rent a place to sleep, buy a car to drive back and forth, and waste a lot of time doing so.
It makes more sense to work where you live than to live where you work. If that makes any sense
It's even more feasible now than it was 20 years ago... no more rows of file cabinets or bookcases full of reference material. Equipment of all kinds is getting smaller and more efficient all the time. And you can video conference with anybody, anywhere, any time.
It's usually better to have the work-space separate from the living space. It should be on a different floor or at least a dedicated room. For example, it used to be normal for people to live in an apartment upstairs from their business. Once I walk out to my office, I am "at work" and generally stay out of the house during the day, except short breaks for lunch, workout, or to change the laundry or something.