Breaking: Antibody Infusion Safely Suppresses HIV Virus

  • metta

    Posts: 39104

    Dec 25, 2015 2:04 AM GMT
    BREAKING: ANTIBODY INFUSION SAFELY SUPPRESSES HIV VIRUS

    "A new study has found that just one infusion of an antibody called VRC01 can safely suppress the level of HIV in the blood of people who are not taking antiretroviral therapy (ART), the National Institutes of Health (NIH) announced late Thursday."


    http://www.hivequal.org/hiv-equal-online/breaking-antibody-infusion-safely-suppresses-hiv-virus
  • Posted by a hidden member.
    Log in to view his profile

    Dec 25, 2015 3:07 PM GMT
    Naturally good news. Questions I have: how does this affect contagion? The article said HIV remained present in cells. It was suppressed, not eliminated.

    Second, does this improve immune system function? I would presume it does. And a weakened immune system is what leads to most additional health problems, referred to collectively as AIDS. If this will reduce the onset of AIDS that's wonderful.
  • Posted by a hidden member.
    Log in to view his profile

    Dec 25, 2015 8:19 PM GMT
    Art_Deco saidNaturally good news. Questions I have: how does this affect contagion? The article said HIV remained present in cells. It was suppressed, not eliminated.

    Second, does this improve immune system function? I would presume it does. And a weakened immune system is what leads to most additional health problems, referred to collectively as AIDS. If this will reduce the onset of AIDS that's wonderful.


    http://stm.sciencemag.org/content/7/319/319ra206
  • Posted by a hidden member.
    Log in to view his profile

    Dec 25, 2015 9:55 PM GMT
    desertmuscl said
    Art_Deco saidNaturally good news. Questions I have: how does this affect contagion? The article said HIV remained present in cells. It was suppressed, not eliminated.

    Second, does this improve immune system function? I would presume it does. And a weakened immune system is what leads to most additional health problems, referred to collectively as AIDS. If this will reduce the onset of AIDS that's wonderful.


    http://stm.sciencemag.org/content/7/319/319ra206


    Don't expect Art Deco to understand any HIV medication. He has gone on record as a non-believer in medical science.

    Art_Deco said

    "So all this BS about sex being safe with an undetectable poz guy is just medical talk dealing with controlled conditions. That has no application, bearing or relevance to the real world situations in which you & I actually operate. And such basic medical research shouldn't be misinterpreted to be providing guidance as to how gay men should behave sexually with each other."

    -------------------------------------

    " Among six ART-treated individuals with undetectable plasma viremia, two infusions of VRC01 did not reduce the peripheral blood cell–associated virus reservoir measured 4 weeks after the second infusion. In contrast, six of eight ART-untreated, viremic subjects infused with a single dose of VRC01 experienced a 1.1 to 1.8 log10 reduction in plasma viremia. The two subjects with minimal responses to VRC01 were found to have predominantly VRC01-resistant virus before treatment. Notably, two subjects with plasma virus load <1000 copies/ml demonstrated virus suppression to undetectable levels for over 20 days until VRC01 levels declined. Among the remaining four subjects with baseline virus loads between 3000 and 30,000 copies, viremia was only partially suppressed by mAb infusion, and we observed strong selection pressure for the outgrowth of less neutralization-sensitive viruses. "


    If I understand correctly, it doesn't lower VL in already suppressed ART patients. But could be a 20 day treatment, rather than taking pills every day.

    Secondly, people who have trouble getting to undetectable, this may help them.

    Those with a higher infection, say the newly infected, it would NOT help. They would need to take regular ART therapy to get to undetectable, or at least lower levels and then this 2-3 week therapy.

    Less pills = less forgetting. An injection every 2-3 weeks could help in the cascade to undetectable. And may be less expensive.

    Promising!
  • FitBlackCuddl...

    Posts: 802

    Dec 25, 2015 11:12 PM GMT
    "Breaking: Antibody Infusion Safely Suppresses HIV Virus"

    (sigh) If you do not have HIV to begin with, there is no need to be concerned about the latest "drug du jour"
  • Posted by a hidden member.
    Log in to view his profile

    Dec 26, 2015 1:12 AM GMT
    Thanks for this - interesting.
  • Posted by a hidden member.
    Log in to view his profile

    Dec 26, 2015 9:14 PM GMT
    FitBlackCuddler said"Breaking: Antibody Infusion Safely Suppresses HIV Virus"

    (sigh) If you do not have HIV to begin with, there is no need to be concerned about the latest "drug du jour"


    Sigh?

    The meds WE use are preventing other people from getting infected. Undetectable eliminates a vector.

    WE also enabled PrEP (WE were the drugs guinea pigs) to prevent people from getting infected.

    ANYTHING that makes ART accessible, cheaper, easier and more long lasting is important to the ending of HIV in our life time.

    The more people on PrEP and ART increases your 'pool' of HIV negative choices.

    This is nothing to be glib about. Maybe all you do is cuddle, I don't know. But this does increase your chances to cuddle with someone.
  • Posted by a hidden member.
    Log in to view his profile

    Dec 26, 2015 10:35 PM GMT
    desertmuscl said
    Art_Deco saidNaturally good news. Questions I have: how does this affect contagion? The article said HIV remained present in cells. It was suppressed, not eliminated.

    Second, does this improve immune system function? I would presume it does. And a weakened immune system is what leads to most additional health problems, referred to collectively as AIDS. If this will reduce the onset of AIDS that's wonderful.

    http://stm.sciencemag.org/content/7/319/319ra206

    I read that, and note: "These data demonstrate the virological effect of this neutralizing antibody and highlight the need for combination strategies to maintain virus suppression."

    But it does not appear to address my question about continued contagion risk to others. Did I miss that?
  • Posted by a hidden member.
    Log in to view his profile

    Dec 26, 2015 10:50 PM GMT
    timmm55 said
    Don't expect Art Deco to understand any HIV medication. He has gone on record as a non-believer in medical science.

    Excuse me? I'm actually on record as quoting from the official US Centers for Disease Control (CDC). I paste directly from them verbatim, unedited, and post their links. If that's not medical science then I don't know what is.

    Versus yourself, offering us biased self-serving personal opinions, dubious sources, and life-threatening advice.

    Well, yah know, if guys here are to choose between you, and the US CDC guidance that I and others post on RJ, that's their decision. But to say I'm a non-believer in medical science, when credible medical science that I cite is what I'm drawing upon, is ultra wacko.
  • FitBlackCuddl...

    Posts: 802

    Dec 27, 2015 5:05 PM GMT
    timmm55 said
    FitBlackCuddler said"Breaking: Antibody Infusion Safely Suppresses HIV Virus"

    (sigh) If you do not have HIV to begin with, there is no need to be concerned about the latest "drug du jour"


    Sigh?

    The meds WE use are preventing other people from getting infected. Undetectable eliminates a vector.

    WE also enabled PrEP (WE were the drugs guinea pigs) to prevent people from getting infected.

    ANYTHING that makes ART accessible, cheaper, easier and more long lasting is important to the ending of HIV in our life time.

    The more people on PrEP and ART increases your 'pool' of HIV negative choices.

    This is nothing to be glib about. Maybe all you do is cuddle, I don't know. But this does increase your chances to cuddle with someone.


    Whether or not these "drugs du jour" are available, I am able to cuddle with 100% of people.
  • Posted by a hidden member.
    Log in to view his profile

    Dec 27, 2015 7:39 PM GMT
    Art_Deco said
    timmm55 said
    Don't expect Art Deco to understand any HIV medication. He has gone on record as a non-believer in medical science.

    Excuse me? I'm actually on record as quoting from the official US Centers for Disease Control (CDC). I paste directly from them verbatim, unedited, and post their links. If that's not medical science then I don't know what is.

    Versus yourself, offering us biased self-serving personal opinions, dubious sources, and life-threatening advice.

    Well, yah know, if guys here are to choose between you, and the US CDC guidance that I and others post on RJ, that's their decision. But to say I'm a non-believer in medical science, when credible medical science that I cite is what I'm drawing upon, is ultra wacko.


    SO you didn't say " such basic medical research shouldn't be misinterpreted to be providing guidance as to how gay men should behave sexually with each other."?

    If you agree with the CDC you should agree with this (it's on their web site, it from Dec. 2015):

    Today, more tools than ever are available to prevent HIV. In addition to limiting your number of sexual partners, never sharing needles, and using condoms the right way every time you have sex, you may be able to take advantage of newer medicines such as pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP).

    There are many actions you can take to lower your risk of transmitting HIV to a partner. The more actions you take, the safer you can be.

    The most important thing you can do is to take medicines to treat HIV infection (called antiretroviral therapy, or ART) the right way, every day. These medicines reduce the amount of virus (viral load) in your blood and body fluids. They can keep you healthy for many years and greatly reduce your chance of transmitting HIV to your partners if you have a very low or undetectable viral load.

    http://www.cdc.gov/hiv/basics/prevention.html

    Is ACON not a good source either? They also recognize PrEP, ART and also condoms. (see above, I've posted it a 100 times). Note that the CDC recognizes the risks of condoms also. Are they good? Yes of course. Are they perfect, or the best? No.

    The only 'ultra wacko' one here is you who disavows current medical studies. FYI the CDC doesn't do studies. They evaluate them, to make sure of their accuracy and follow guide lines.

    At one point you said I got Dr. Fauci to agree with my "BB agenda"...do you remember that? The absurdity is comical.

    http://www.realjock.com/article/1546/

    I get it, you like what is old and proven. I disagree, there needs to be more...and there is.

    Oh and your question "does it improve immune function?" Of course it does. It makes them undetectable, for some that couldn't with ART alone.

    Did you read any blame from the CDC? That someone is not 'guilty' if they got HIV early, when it was GRID? But someone IS guilty if they get HIV now? No, of course not. The CDC doesn't stigmatize like YOU do. That is YOU, your guilt association. The CDC is against stigma, blame and YOU.







  • Tawrich

    Posts: 62

    Feb 05, 2016 10:22 AM GMT
    Strange that someone is linking primary literature published in science translational medicine and equally understandable that the interpetation is going all over the place. Primary literature is nice but these journals are not designed to be read by the lay public. The idea is to look at the data instead of believing what the authors say in the abstract and most people on RJ don't have subscriptions to Science.

    This is actually isn't that exciting of a trial. It takes longer for the MUCH higher cost antibody infusion (around 30k+ a year with insurance for therapies that have been on the market for a while now) to suppress the virus in comparison to ART. The patients weren't followed long term to determine how quickly the virus rebounds. So far it's only been tested in a small number of patients largely to determine side effects and there are already signs that many variants of HIV won't respond to this. There is no additive benefit for people already on ART. Additionally this is an injection therapy as opposed to taking a pill.

    What is exciting about this is that the antibody blocks the virus before it enters cells making it exciting as an emergency post exposure therapy. There are only a few drugs on the market that are capable of doing this. There should be fewer side effects as well. It also shows that a single antibody might be protective for many people as opposed to a pool of antibodies. Vaccine developers have been trying to drive the human immune system to make broadly protective antibodies for a while but it's been extremely difficult. This at the very least gives hope for a successful HIV vaccine.