I know that the area that I'm in, the local cities are rezoning anything that was manufacturing on major streets to mixed use (retail/housing) in order to increase revenues for the cities. The result is manufacturing is either paying a lot more for rent (because there is a lot less available) or moving farther out. Every little space that can be developed is being developed. Many places are being town down and redeveloped.
The cost of housing, owning and renting, has increased a lot in the last 5 years. I could see why people would move out, especially if they are having a tough time here. However, if they are able to find a way, a lot of times those people end up coming back.
California is really the only state I would consider living in. I do plan on moving eventually but I'm hoping to find a place in another part of the State.
Toyota was one of the few exceptions of a major company leaving that paid their employees well. Most are companies that left pay workers low wages and don't want to bound by environmental regulations. Because of the cost of living here, it does not make a lot of sense to have companies that pay their workers low wages.