My Performance Eating and Epigenetics Statement / 3/5/2017 Update: Watch the Doctor's Presentation at AANMC)

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    Feb 14, 2017 4:20 PM GMT
    Please articulate what we are doing by approving or correcting my draft. "Agglutination occurs in the circulatory system, the lymphatic system, the nervous system, in the glands, and in the organs. The anniversary edition teaches us not metabolism in general but carbohydrate metabolism improves with food selection right for our blood type. The anniversary edition teaches us that our microbiome can be optimized by eating for our blood type. [Blood type is to be understood to go further with secretor status. That's why I use Live Right 4 Your Type over Eat Right for Your Type.]

    Although there is an ABO gene, Dr. D has food choices (epigenetic choices) that are not always in sync with the ABO gene food choices. To cover ABO gene and non-ABO gene food choices, I also follow the Genotype diet. I will limit ABO gene food choices that are not also beneficial for non-ABO gene food choices." Thank you, Stephen
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    Feb 14, 2017 4:49 PM GMT
    Reply:

    http://northamericanpharmacal.com/living/2015/10/3207/

    Stephen

    "Living things manufacture agglutinins in a GREAT VARIETY of SHAPES and FORMS, and they don’t share any real characteristics other than the ability to clump sugars together."
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    Feb 14, 2017 4:51 PM GMT
    Naturopathic Doctor D'Adamo

    Lectins are similar to a selective Velcro, a powerful way for organisms in nature to attach themselves to other organisms in nature. This natural Velcro comes in two varieties, one-sided and two-sided. The one-sided variety just gets stuck on things. Lots of germs, and even our own immune systems, use the one-sided variety all the time. Cells in the bile ducts of the liver have lectins on their surfaces to help them snatch up bacteria and parasites. Bacteria and other microbes have lectins on their surfaces that work rather like suction cups so that they can attach to the slippery mucus linings of the body. Sometimes the lectins that viruses or bacteria use can be blood group specific, making the microbe a stickier pest for a person of the favored blood group.
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    Feb 14, 2017 4:55 PM GMT
    Interesting:

    Many lectin-containing foods evade cooking because they are normally eaten raw, such as tomatoes, now the primary vegetable source of vitamins and minerals in the U.S. diet. Unlike most lectins, which usually react with only one blood group or another, tomato lectin is a panagglutinin; it is able to attach itself with equal ease to the cells of all blood groups.
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    Feb 14, 2017 5:02 PM GMT
    Stephenoabc
    NOT PRECISELY CORRECT that agglutination is only about red blood cells clumping because he goes on to say:

    Studies show that up to 5% of the ingested dietary lectins are absorbed into the bloodstream. There they can clump and bind to red AND WHITE BLOOD CELLS, DESTROYING THEM. ... However, the actions of food lectins on the digestive tract are probably much more potent. Here they can cause inflammation of the mucus linings, and mimic many of the symptoms of food allergies.
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    Feb 14, 2017 5:25 PM GMT
    The lymphatic system transports white blood cells to and from the lymph nodes into the bones.

    So, when we read:
    - studies show that up to 5% of the ingested dietary lectins are absorbed into the bloodstream;
    - there they can clump and bind to red and white blood cells, destroying them,

    the question becomes:
    the destruction occurs in the circulatory system--white blood cells are destroyed before being able to get to the lymphatic system OR does destruction happens in the lymphatic system also?
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    Feb 14, 2017 5:32 PM GMT
    REMEMBER
    1) Eating Right for Your Blood Type helps one avoid having their white blood cells destroyed.
    2) Agglutination is about red blood cells clumping but lectins can also clump to white blood cells. Red blood cells clumping together do not necessarily destroy each other BUT lectins clumping to red and white blood cells can and do destroy these blood cells.
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    Feb 14, 2017 5:36 PM GMT
    3) We have an edit. The lymphatic system has multiple interrelated functions: It is responsible for the removal of interstitial fluid from tissues. It absorbs and transports fatty acids and fats as chyle from the digestive system. It transports white blood cells to and from the lymph nodes into the bones.
    Therefore the edit seems to be: ER4YT is NOT about the lymphatic system.
    4) Although we count 4 blood types: O, B, AB, and A, we really have at least O, B, AB, A1, and A2
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    Feb 15, 2017 3:17 AM GMT
    Reply:
    So no red blood cells are in our lymph system, just white?

    Stephen
    I asked google: What is transported in the lymphatic system? Reading further: "Lymph is very similar to blood plasma: it contains lymphocytes and other white blood cells. It also contains waste products and cellular debris together with bacteria and proteins."

    The top of the Wikipedia article which was the google result, it says the lymphatic system is part of the circulatory system.
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    Feb 15, 2017 5:02 PM GMT
    Dr. D'Adamo
    It was known early in the last century that the substances (antigens) that determine our ABO blood type often occur in our tissues and secretions, in addition to being fixed on our red blood cells.

    Stephen
    Not as simple as the ABO gene determines our blood type--gene and antigens, unless antigens are part of the gene structure. Google, tell me what the ABO gene is.

    Google
    Histo-blood group ABO system transferase is an enzyme with glycosyltransferase activity, which is encoded by the ABO gene in humans.[4][5] It is ubiquitously expressed in many tissues and cell types.[6] ABO determines the ABO blood group of an individual by modifying the oligosaccharides on cell surface glycoproteins. Variations in the sequence of the protein between individuals determine the type of modification and the blood group. The ABO gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.

    Stephen
    Google, what is SNP. Acronyms should not be used without what they stand for the first time they are used.

    Google:
    A single-nucleotide polymorphism, often abbreviated to SNP (/ˈsnɪp/; plural /ˈsnɪps/), is a variation in a single nucleotide that occurs at a specific position in the genome, where each variation is present to some appreciable degree within a population (e.g. > 1%).

    Dr. D'Adamo
    These blood type antigens are found in two basic forms: a water-soluble version and an alcohol-soluble version.
    Secretors have more water-soluble substances in their tissues than those lacking the substance in their saliva, known as non-secretors.
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    Feb 15, 2017 5:04 PM GMT
    What is going on now?

    Stephen:
    I was sent a second and a third link. I'm going through the second link:
    Blood Type and the Microbiome
    http://northamericanpharmacal.com/living/2015/05/blood-type-and-digestion-102-the-microbiome/
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    Feb 15, 2017 5:07 PM GMT
    Interesting: Non-secretors are much more likely to be carriers of Candida albicans yeast and to have problems with persistent Candida infections.
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    Feb 15, 2017 5:10 PM GMT
    The protective effect afforded by the secretor gene might be due to the ability of blood type antigens in the body fluids of secretors to block sticky molecules called adhesins, attachment lectins that lie on the surface of the yeast and allow it to attach to the tissues. In one study, among individuals with Type II diabetes, 44% of nonnies (of all ABO types) were oral carriers of this yeast.

    Stephen: I guess I better go French kiss some non-secretors--just making a statement to help me retain the information.
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    Feb 15, 2017 5:12 PM GMT
    Hm, maybe I do need to give out French kisses given this:

    Although nonnies make up only about 20% of the population, they are significantly over represented among individuals with either oral or vaginal Candida infections, making up almost 50% of affected individuals. (2) Their inability to secrete blood group antigens in saliva also appears to be a risk factor in the development or persistence of chronic candidiasis. In one study, the proportion of non-secretors of blood group antigens among patients with chronic candidosis was 68%. (3) Women with recurrent vaginal candidiasis are much more likely to be nonnies.
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    Feb 15, 2017 5:15 PM GMT
    Wouldn't you know it: started talking about the microbiome and you have to start talking about feces and fecal matter.
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    Feb 15, 2017 5:27 PM GMT
    Dr. D'Adamo:
    Human feces contain enzymes produced by the bacteria of the microbiome that degrade (digest) the ABO blood type antigens that line your digestive tract.
    Stephen:
    Human feces contain enzymes? Digestion should be over so far as the host is concerned. But if there are enzymes there, so be it.
    These enzymes come from the bacteria in the microbiome.
    Those bacteria degrade antigens that line your digestive tract.
    Does my digestive tract need these antigens? Is this a good thing, the degrading of antigens that line your digestive tract?
    Do the good bacteria do this or do the bad bacteria do this. Earlier, the article said "There is surprising evidence that many of the bacteria in your microbiome like to ‘eat right for their blood type.’" SO, do ER4YT food help the process but not eating right for your type hinder this process--OR WORSE: IS DYSFUNCTIONAL. LOL.
    Dr. D'Adamo:
    There is good evidence that the ABO blood type and secretor status are a major influence on the specificity of these bacterial enzymes produced the microbiome.
    Stephen:
    There's a typo: should be produced by the microbiome. Back to the content, yes, I've bought the eat right for your type probiotics. Dr. D'Adamo himself told me optimize my probiotic supplementation with ER4YT probiotics.
    Dr. D'Adamo:
    The population of fecal bacteria that produce blood group-degrading enzymes is highly correlated with the ABO /secretor type of the host: Fecal populations of blood type B-degrading bacteria were stable over time and their population density averaged 50,000-fold greater in blood group B secretors than in other subjects.
    Stephen:
    And what about O, A, and AB?
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    Feb 15, 2017 5:50 PM GMT
    Dr. D'Adamo:

    Take Home Message:
    If you suffer from 1) Chronic yeast infections, 2) Inflammatory problems of the digestive tract, 3) Allergies, 4) Carbohydrate intolerance, 5) Auto-immune problems, I recommend that you look into getting your secretor status determined. You might find that integrating the suggested changes to your basic ABO blood type diet that result from knowing your secretor status can make all the difference in the World when it comes to improving your results.

    Stephen:
    See, that's why I have to have the book Live Right 4 Your Type. For six months, I probably need to try Polyflora O instead of the probiotics at Whole Foods. Second, I knew and know of people with those problems. "Doctors go to school, are you a medical doctor?" They are not receptive. Third, taking probiotics not right for your blood type therefore then become bad bacteria? Fourth, I remember the conversation with Dr. D. I had a book on probiotics. There's quite a list of probiotic types. I was not convinced and still not convinced I only need 1) Streptococcus themophilus, 2) Lactobacillus rhamnosus, and 3) Saccharomyces boulardii. Given my reservations, I still better be getting the three.
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    Feb 15, 2017 5:51 PM GMT
    Yea! I made it to the end of the second link. Enough work for today. (I see two more links were added.)

    Reply
    Check out the Center of Excellence

    Stephen
    Yes, it did cross my mind to use some of my inheritance to live near the Center of Excellence and go there for summer semesters. Astrologically, I now live influenced by a Saturn DS angle. When I lived in NYC, I was influenced by a Venus MC angle. I get no appreciation here and cooperation is not rewarded. So, I cannot expect to make any money off the education. Cost-Benefit analysis, I would have to stay up there to make money by serving others.
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    Feb 15, 2017 5:57 PM GMT
    Oh, that's not a place to get a degree or certification. It's at a university but the Center isn't a place where you take classes.
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    Feb 15, 2017 6:08 PM GMT
    I only see it offers the ND program--no continuing ed or certification programs.
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    Feb 17, 2017 3:15 PM GMT
    Video: What is the Genotype Diet?

    http://northamericanpharmacal.com/living/2015/03/video-dr-dadamo-explains-the-genotype-diet/
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    Feb 20, 2017 6:33 PM GMT
    Biofilms and Herbal Medicine

    Since many of these lectins latch on to sugars, and the most common sugars on our membranes are those of our ABO blood group, it is not surprising to discover that many infections, if not most,have a preference for one blood type or another -another good reason to eat right for your type.

    The actions of cranberry juice on urinary tract infections are thought to be partially the result of the juice's high concentration of the sugar mannose. Mannose is know to block the attachment of two classes of fimbriae: the "type 1" and "p type."

    Quorum Sensing

    A fascinating example of the level of cooperation that occurs during biofilm formation is a phenomena called quorum sensing. Like an early pioneer of the American West writing home to describe the wonders of California, the first bacterial colonists secrete a variety of signaling molecules which act on receptors of other bacteria, inducing them to alter their own genes. This allows them to adhere to the biofilm and produce additional signaling molecules of their own to attract additional followers. Quorum sensing is not limited to bacteria: it can be observed in many social species such as ants and honey bees.

    "A bacterial quorum is not unlike the human variety - as soon as enough individuals are gathered together, decisions can be made. For bacteria, these decisions result from the production of signals that switch on genes involved in processes such as virulence."

    - Alison Mitchell [Nature Reviews Molecular Cell Biology 2, 488 (July 2001)]


    ET call home: Signaling for biofilms

    Biofilms are an object of intense scrutiny in biomedicine ...

    Stress and biofilms

    The stress hormone norepinephrine affects parts of the brain where attention and responding actions are controlled. Along with epinephrine, norepinephrine also underlies the fight-or-flight response, directly increasing heart rate, triggering the release of glucose from energy stores, and increasing blood flow to skeletal muscle. Norepinephrine is synthesized from dopamine by dopamine β-hydroxylase. The gene for dopamine β-hydroxylase has shown some association linkages with the gene that controls ABO blood type. ( 8 )

    Norepinephrine can substitute for the AI-3 auto-inducer and result in biofilm growth. Both epinephrine and norepinephrine are present throughout the gastrointestinal tract. Since the major link between ABO and dopamine appears to be via the null alleles (people who are type O blood) we could hypothesize that blood group O individuals, who are highly stressed (or otherwise hyper-adrenalized), may have more problems with infections or overgrowth in the gut. This may be especially relevant for those type O individuals who possess the "Hunter" epigenotype.

    Herbal medicine and biofilms

    I've been using this herbal combination in my practice for chronic, stubborn or otherwise long-lasting infectious states. Its components address many of the issues that I've discussed above.

    Seaweeds

    Seaweeds are well-known to possess an amazing ability to resist biofilm formation. This is probably an evolutionary adaptation to the harsh demands of having to eek out a living at the interface of land and sea, a bioterrain full of life and threats. Marine scientists and surgeons from Newcastle University are currently developing a nasal spray that uses the enzyme NucB found in seaweed to help clear chronic sinusitis. When tested on biofilms from 24 different strains of sinusitis bacteria, NucB broke through and dispersed 58 percent of them. Once these biofilms are dispersed, the released bacteria are helpless against the very antibiotics they once repelled as a group. (20,21)

    Andrographis paniculata

    Since ancient times, Andrographis has been used in traditional Siddha and Ayurvedic systems of medicine as well as in tribal medicine in India and some other countries. The plant extract exhibits antityphoid and antifungal activities. (9) Andrographis is also reported to possess hepato-protective, antibiotic, antimalarial, and anti-inflammatory properties. (10)

    Andrographolide, the main active component of the herb Andrographis paniculata was recently reported to act by inhibiting the bacterial quorum sensing system. (11) A recent study using variations (analogues) of andrographolide verified this observation. (12)

    Andrographis has unquestioned activity in chronic respiratory problems. I think the next few years will witness this plant assuming precedence in infectious disease management that few herbs (with perhaps the exception of Artemesia annua for malaria) ever achieve.

    Scutellaria baicalensis

    Chinese Skullcap flavonoid is a member of the mint family and has long been used in traditional Chinese herbal medicine, as a digestive aid, and to normalize an over-active digestive system. Scutellaria has been shown to decrease inflammatory cytokine production from human mast cells (immune system hormones which ramp up inflammation). Scutellaria also has a cell-regulating effect; encouraging the body to more efficiently remove cells which have become dysfunctional, either though age or malformation. (13)

    Baicalein, a flavone found in the leaves of Scutellaria, has been shown to affect the ability of bacteria to adapt to antibiotics. Bacteria become resistant to medication such as antibiotics by maximizing their ability to flush them out of their cell bodies. Scutellaria blocks this by inhibiting the removal (efflux) of the drug through what are called MDR (multiple drug resistance) pumps. When used with antibiotics, Baicalein noticably increased the efficacy of several antibiotics. (14)

    Chinese Skullcap has a variety of actions in the body but I've found that the real benefit of the herb in instances of infection is its remarkable ability to limit the ability of microbes to develop resistance to medication. There is also some evidence that Chinese Skullcap is directly damaging to the bacteria outer membrane as well.

    Schisandra chinensis

    A renowned herb in Chinese medicine, Schisandra invigorates the RNA-DNA molecules to reconstruct cells and enhance the fitness of the adrenal glands. Adaptogenic herbs, like schisandra, have been used in Traditional Chinese Medicine to improve the ability of the body to respond to stress. (15) The major constituents in schisandra are lignans (schizandrin, deoxyschizandrin, gomisins, and pregomisin) found in the seeds of the fruit. Modern Chinese research suggests these lignans have a protective effect on the liver and an immunomodulating effect. (16)

    Rhizoma Atractylodis Macrocephalae

    Practitioners of Chinese medicine believe that Atractylodes affects the Spleen and Stomach meridians, or energy pathways in the body, serving as a "Spleen Qi tonic," meaning that it rebuilds metabolic function by increasing nutrition, increasing energy, and regulating fluids. White Atractylodes is also thought to have restorative, normalizing effects on the digestive system and liver. (17)

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    Feb 20, 2017 6:49 PM GMT
    Eleutherococcus senticosus

    This herb is also known as Siberian ginseng. The applicable parts of Siberian ginseng are the root and leaf. The lignin constituent sesamin, and the phenylpropanoid syringin seem to have immunostimulatory effects. ( 18 ) Long known as an adaptogen, Siberian Ginseng is considered to possess stress-modulating effects, including optimization of the HPA (hypothalamus-pituitary-adrenal "fight or flight" stress axis. Siberian ginseng and Schisandra chinensis stimulate the expression of chemicals (Hsp70, Hsp72) involved in the chemical defense against stress. (19)

    I like using these herbs in an otherwise rather "allopathic" formula since it is important to remember that tissue repair and healing is critical to preventing recurrence. Stress seems to really impact biofilm formation, so controlling (modulating) noradrenaline levels in the gut makes a lot of sense.

    This herbal approach works well with whatever anti-lectin therapy (diet, anti-adhesion supplements) I'm using with the patient.

    Two Product resources I commonly use for difficult or resistant problems associated with biofilms:

    Genoma Security: For the Astragalus and Andrographis elements
    Fucus Plus: For the biofilm-inhibiting properties of seaweeds

    Yours In Health,
    Dr. Peter D'Adamo
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    Feb 20, 2017 6:50 PM GMT
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    Feb 20, 2017 6:54 PM GMT
    Rewrite "My High Performance Eating and Epigenetics Statement."