My Estradiol Is Normal But My Estrogen Is High - Culprit May Be XenoEstrogens (Environmental)

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    Jun 27, 2017 5:42 PM GMT
    Xenoestrogens are found in a variety of everyday items. Many of us don’t think twice about the makeup we wear each day or the plastic container we use to pack our lunch. We know organic food is supposed to be better for us, but sometimes we just don’t want to pay the extra money. Unfortunately, all of the above may be altering the way our body naturally functions because they all contain endocrine disruptors called, xenoestrogens.
    Endocrine disruptors are a category of chemicals that alter the normal function of hormones.  Normally, our endocrine system releases hormones that signal different tissues telling them what to do. When chemicals from the outside get into our bodies, they have the ability to mimic our natural hormones; blocking or binding hormone receptors. This is particularly detrimental to hormone sensitive organs like the uterus and the breast, the immune and neurological systems, as well as human development.
    Xenoestrogens are a sub-category of the endocrine disruptor group that specifically have estrogen-like effects. Estrogen is a natural hormone in humans that is important for bone growth, blood clotting and reproduction in men and women. The body regulates the amount needed through intricate biochemical pathways. When xenoestrogens enter the body they increase the total amount of estrogen resulting in a phenomenon called, estrogen dominance. Xenoestrogens are not biodegradable so, they are stored in our fat cells. Build up of xenoestrogens have been indicated in many conditions including:  breast, prostate and testicular cancer, obesity, infertility, endometriosis, early onset puberty, miscarriages and diabetes.
    Below is a list of some of the sources of xenoestrogens ...

    See
    https://womeninbalance.org/2012/10/26/xenoestrogens-what-are-they-how-to-avoid-them/
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    Jun 27, 2017 5:47 PM GMT
    https://womeninbalance.org/2012/10/26/xenoestrogens-what-are-they-how-to-avoid-them/

    I'm going to have to throw away my two 3-gallon, plastic, water bottles.

    And what, get six 1-gallon, glass, water bottles.

    I don't want six little children in my small kitchen.

    Oh eff you. What else can we do?

    I hate it when there's no other way out.
    EFF!

    And, we've got to get rid of those three plastic protein shaker bottles.

    Oh MY GAWD! WTF!!!!
  • LostSailor

    Posts: 234

    Jun 30, 2017 6:37 PM GMT
    OR you could just take Arimidex and be done with it???
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    Jun 30, 2017 9:10 PM GMT
    So BPA free plastic, as used in food storage containers, protein powder shaker containers and those half- and one-gallon water jugs manufactured specifically for gym reuse are problematic?
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    Jul 02, 2017 12:11 AM GMT
    OP: It's your weight, not the environment, which is messing with your hormones.

    See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770848/
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    Jul 07, 2017 4:36 AM GMT
    bachian saidOP: It's your weight, not the environment, which is messing with your hormones.

    See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770848/


    Adipose tissue, or fat, is an anatomical term for loose connective tissue.

    Within fat tissue, enzymes such as aromatase and aldo-keto reductase 1C are responsible for metabolizing testosterone into estrogen.

    The role of adipose tissue had begun to gain attention, in that its role could include not only

    1 the storage of triglycerides but also

    2 the secretion of metabolic proteins. Leptin, now known to be released from adipose tissue, regulates the appetite, the balance of energy, and endocrine function, as well as the immune system.

    3 Other than leptin, adipokines such as adiponectin, resistin, and retinol binding protein are secreted from adipose tissue, affecting insulin resistance.

    Furthermore, several studies have suggested that tumor necrosis factor α (TNFα) and interleukin-6, one of the most important cytokines of inflammation, are associated with adipocytes. In one study, it has been observed that visceral fat tissue promotes systemic inflammation by secreting cytokines into portal circulation. This systemic inflammation has an effect on insulin signaling and causes insulin resistance.

    The concentrations of circulating sex hormones are influenced by the amount and distribution of the adipose tissue.

    An increased level of testosterone in the bloodstream had caused a rise in insulin sensitivity.

    Testosterone was identified to have a negative correlation with obesity.

    50% of testosterone in adult males is bound to albumin.

    44% is bound to sex hormone binding globulin (SHBG),.

    2~3% stays free-form.

    SHBG is known to decrease the metabolic clearance rate of testosterone and interrupts its movement into cells thus, bioavailable testosterone from the tissues is in the unbound as well as the albumin-bound form.

    = = =

    Obesity has an impact on the hypothalamus-pituitary-testicular axis; a study on obese males showed that the Body Mass Index had a negative correlation with the concentration of testosterone and a positive correlation with estradiol.

    An increase in pro-inflammatory cytokines such as TNFα from adipose tissue influences the secretion of gonadotropin in the pituitary.

    An androgen is any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.

    Androgen inactivation rates were higher in the obese group than the normal group.

    The receptors for androgen are present in adipose tissue, and are more prominent in visceral (VAT) than subcutaneous adipose tissue.

    = = =

    Bachian,

    My physician gave me some summary advice in line with the above.
    Yes, my BMI is too high and I'm working on that.
    My increased Omega 3 and Omega 7 is allowing me to move better which is increasing my exercise endurance.

    And, resistance training increases testosterone--and I am 55, not 25.

    I do not think the information you provided negates:

    1) The body produces estrogen
    2) Phyto-estrogen intake increases estrogen, for example, soy intake
    3) Xeno-estrogen comes not from body production but from the environment