Phthalates and Bad Estrogen Metabolites - What Do You Do about Them?

  • Posted by a hidden member.
    Log in to view his profile

    Jul 22, 2017 10:56 PM GMT
    Phthalates (US: /ˈθæleɪts/,[1] UK: /ˈθɑːleɪts/[2]), or phthalate esters, are esters of phthalic acid and are mainly used as plasticizers (substances added to plastics to increase their flexibility, transparency, durability, and longevity). Phthalates are manufactured by reacting phthalic anhydride with alcohol(s) that range from methanol and ethanol (C1/C2) up to tridecyl alcohol (C13), either as a straight chain or with some branching. They are divided into two distinct groups, with very different applications, toxicological properties, and classification, based on the number of carbon atoms in their alcohol chain. They are used primarily to soften polyvinyl chloride (PVC). Lower-molecular-weight phthalates (3-6 carbon atoms in their backbone) are being gradually replaced in many products in the United States, Canada, and European Union over health concerns.[3][4] They are replaced by high-molecular-weight phthalates (those with more than 6 carbons in their backbone, which gives them increased permanency and durability). In 2010, the market was still dominated by high-phthalate plasticizers; however, due to legal provisions and growing environmental awareness and perceptions, producers are increasingly forced to use non-phthalate plasticizers.[5]

    Phthalates are used in a wide range of common products, and are released into the environment.[6] There is no covalent bond between the phthalates and plastics; rather, they are entangled within the plastic as a result of the manufacturing process used to make PVC articles.[7] They can be removed by exposure to heat or with organic solvents. Due to the ubiquity of plastics (and therefore plasticizers) in modern life, the vast majority of people are exposed to some level of phthalates, and most Americans tested by the Centers for Disease Control and Prevention have metabolites of multiple phthalates in their urine.[8] Phthalate exposure may be through direct use or by indirect means through leaching and general environmental contamination. Diet is believed to be the main source of di(2-ethylhexyl) phthalate (DEHP) and other phthalates in the general population.[8] Fatty foods such as milk, butter, and meats are a major source.[9] In studies of rodents exposed to certain phthalates, high doses have been shown to change hormone levels and cause birth defects.

    The average phthalate intake is 3 mg.
    Far Infrared Sauna removes them from the body.
  • Posted by a hidden member.
    Log in to view his profile

    Jul 22, 2017 10:59 PM GMT
    Maybe glucuronidation may help.
    There is Calcium D-Glucurate. You won't find this in the Calcium section. It's in women's health, likely for breast cancer. However, men are at risk for bad estrogen metabolites.

    Here's an article about estrogen metabolites.

    Constructive Comments will be appreciated.
  • Posted by a hidden member.
    Log in to view his profile

    Jul 22, 2017 11:10 PM GMT
    Let's Complicate Things:

    For the most part, Calcium-D-Glucarate is just known to be a β-glucuronidase inhibitor via its metabolite D-glucaro-1,4-lactone.

    The process of 'glucuronidation' is a detoxification process where a group (known as a glucuronide) is attached to a hydrophobic molecule to make it more water soluble, and then the kidneys can better facilitate its removal from the body. This process is positively mediated by the glucuronosyltransferase enzyme, and negatively mediated by the β-glucuronidase enzyme; as such, inhibiting the negative regulator (the enzyme that removes the glucuronide) indirectly increases the activity of this pathway.

    It is touted to be an anticancer agent, which is due to a series of past research done in rats and mice exposed to the DMBA toxin which is known to be glucuronidated. There are definitely anticancer effects in these models, and it appears to extend to other toxins that are glucuronidated.

    However, a problem occurs when humans take this as an oral supplement. Although it appears to be safe even at high doses, very high doses are required for its effects (100mg/kg minimum, near maximal effects at 200mg/kg) and this would even only theoretically assure some protection against toxins that are glucuronidated. If a toxin is subject to another detoxification pathway (such as conjugation by glutathione) then Glucaric acid will serve no benefit.

    Organ cancer production which just occurs spontaneously because of oxidative stress to DNA is also not likely to be protected against, as increasing glucuronidation does not per se decrease oxidative stress in the body (it might just reduce the oxidative effects of toxins).

    Furthermore, all steroid hormones in the body (testosterone, estrogen, DHEA, etc.) are also glucuronidated. If using

    an oral dose that reduces the toxin,

    these hormones will also all be reduced for a short time.

    Using calcium-D-glucarate as a daily preventative supplement does not appear to be a prudent idea, due to its lack of reliability even in theory and high doses used.

    However, a single acute dose of this supplement prior to known exposure to toxins that are glucuronidated (such as both benzopyrene and polyaromatic hydrocarbon compounds produced in the cooking of meat products) might be more prudent and potentially useful.

    = = =

  • Posted by a hidden member.
    Log in to view his profile

    Jul 22, 2017 11:14 PM GMT
    Lets complicate things even further.

    The pathway the body uses to detoxify your daily plastics, glucuronidation, is revved up not only by taking Calcium D-Glucurate but by eating

    Brussels sprouts
    collard greens

    = = =

    Try to avoid foods in plastic.

    Yea, right.

    Uhm, you betta get your $200 and buy some Far InfraRed Sauna sessions, PlasticBoy.
    And do your weight lifting to try to maintain your steroid hormone, testosterone.
  • Posted by a hidden member.
    Log in to view his profile

    Jul 22, 2017 11:22 PM GMT
    Estrogen Metabolites in Men

    National Institutes of Health Library Article:

    Estrogen Metabolism in Men

    In studies of men's capacity for estrogen inactivation in health and disease, it was observed that patients with prostatic cancer had enhanced ability to inactivate estrogenic hormones. This ability might well lead to excessive androgen stimulation, thereby providing favorable hormonal environment for the development of prostatic cancer.

    Extension or regression of the malignant process did not affect this peculiar pattern of estrogen metabolism. It is possible, therefore, that the pattern may not be related to the cancer process itself but to some inherent tendency in the individual. Upon speculation as to whether or not this tendency is found in the liver, which is known to be the principal site of estrogen inactivation, studies of patients with liver damage were carried out and the results indicated that the liver possesses a tremendous reserve for inactivation of the estrogens in men.

    Studies on estrogen concentration in the bile indicated that estrogens are not eliminated rapidly from the human body through the biliary tract. However, this does not hold true for experimental animals.

    Observations on endogenous estrogen excretion in men did not support the concept that benign prostatic hypertrophy is due to an elevated estrogen-androgen ratio.
  • Posted by a hidden member.
    Log in to view his profile

    Jul 22, 2017 11:29 PM GMT
    What do perimenopause, premenstrual syndrome, enlarged prostate glands, and early heart attacks have in common?  Estrogen.  A new understanding of healthy estrogen metabolism is providing a natural treatments for these and other important conditions confronting both women and men.
    Fortunately, phytonutrients discovered in cruciferous vegetables offer a natural approach to resolving estrogen imbalance.  Dietary supplementation with an absorbable form of one of these phytonutrients, called Di-Indoly Methane (DIM), helps promote healthier estrogen metabolism.  DIM's hormonal balancing effects have revealed these midlife problems are not due to estrogen itself alone, but rather, to estrogen metabolism imbalances.

    Q.  What is DIM, and how can it help hormones?
    A.  DIM is a phytonutrient (plant nutrient) found in cruciferous vegetables.  These include cabbage, broccoli, bok choy, Brussels sprouts, cauliflower, kale, kohlrabi, mustard, rutabaga, and turnip.  These plants have been cultivated for thousands of years and were initially used for their medicinal benefits.  The connection between DIM and hormones like estrogen has to do with similar characteristics between them at the molecular level.  DIM is not an estrogen or a hormone, but like estrogen it shares the common characteristic of being poorly soluble in water.  Like estrogen, DIM can be metabolized only by a special class of cytochrome enzymes that reside in cell membranes in the non-water part of cells.  It turns out that DIM, when consumed in food or in absorbable formulations, encourages its own metabolism.  This special metabolic pathway for DIM, and the enzymes involved, precisely overlap with the pathway needed for healthy estrogen metabolism.
    Stated simply, supplementing the diet with DIM specifically promotes beneficial estrogen metabolism and helps restore a healthy hormonal balance.

    Q.  What is estrogen dominance?
    A.  Middle-aged men and women experience changes in hormone production and metabolism resulting in excess estrogen action.  There are three basic forms of this common imbalance known as estrogen dominance.
    Perimenopause.  In women, slower hormone metabolism in midlife can mean higher-than-normal levels of estrogen and a deficiency in its healthy metabolites.  Faltering estrogen metabolism often occurs in women during perimenopause, the years before menopause, and is characterized by higher monthly estrogen levels prior to estrogen's dramatic fall at menopause.(2)  Additionally, progesterone levels fall during perimenopause, resulting in a rising estrogen-to-progesterone ratio.
    Middle-aged men.  Rising estrogen also becomes a problem for men during their 50s and 60s.  In overweight men, testosterone is increasingly converted into estrogen by aromatase and rising estrogen also competes with falling testosterone.  This corresponds to a time during which estrogen accumulates in the prostate gland.  Estrogen is believed to contribute to benign prostatic hypertrophy (BPH).(3)
    Acquired estrogen imbalance.  This important form of estrogen dominance has to do with inherited problems in estrogen metabolism and influences of diet and chemicals on beneficial metabolite production.  Acquired estrogen imbalance affects both men and women.  Almost 20 years ago, H. Leon Bradlow, Ph.D., a renowned breast cancer investigator, discovered women with breast and uterine cancer made too little of the 2-hydroxy or "good" metabolite of estrogen and too much of the 16-hydroxy or "bad" variety.(4)
    Since 16-hydroxy is an unregulated form of estrogen prone to behave like "super-estrogen," higher levels create a particularly unhealthy form of estrogen dominance.  16-hydroxy estrogens can result in mutations, abnormal growth (as in cervical dysplasia),(5) and an increased risk of future breast cancer.(6)  Overproduction of 16hydroxy estrogen is also seen in obesity,(7) high-fat diets,(icon_cool.gif and exposure to a host of "estrogenic" environmental chemicals.(9)  Therefore, this dangerous form of estrogen dominance can result from inheritance, diet, and environmental chemicals.

    Q.  What benefits can DIM offer?
    A.  Supplementing our diets with DIM can shift the production of estrogen metabolites away from dangerous 16-hydroxy in favor of beneficial 2-hydroxy metabolites.  Taking DIM in an absorbable formulation encourages active and healthy estrogen metabolism.  DIM supports estrogen balance by increasing beneficial 2-hydroxy estrogens and reducing the unwanted 16-hydroxy variety.  This improves estrogen metabolism and helps resolve all three forms of estrogen dominance.
    NaturoDoc Note:  Remember, 2-hydroxy is good; 16-hydroxy is bad.

    Q.  Why not just eat more cruciferous vegetables?
    A.  Recent reports, like one from the Fred Hutchison Cancer Center in Seattle, Washington indicate a higher intake of cruciferous vegetables is associated with a lower risk of prostate cancer.
    This study indicates cruciferous vegetables are protective for hormone-sensitive cancers.  However, direct measurements of upward, beneficial shifts in estrogen metabolism indicate you would have to eat at least two pounds per day of raw or lightly cooked cruciferous vegetables to derive the same benefit as two capsules of specially formulated DIM.  Benefits for cervical dysplasia, PMS, BPH, and other conditions have not been seen with the use of broccoli, cabbage juice, or dried powders or extracts from vegetables.

    Absorbable DIM formulations overcome the need for active enzymes within the vegetable and chemical reactions in your stomach to produce DIM.  For similar reasons, absorbable DIM provides many advantages over indole-3carbinol (I3C), another cruciferous phytochemical available as a supplement.  I3C is an unstable precursor that requires activation in the stomach to be converted into DIM.  This means I3C must be taken at a much higher dose and can undergo unpredictable and undesirable chemical reactions in your stomach and colon.  DIM, in a delivery system to assure absorption, is by far preferable to the supplemental use of I3C.

    Q.  How can helping estrogen metabolism benefit men?
    A.  Everyone knows estrogen is an important hormone for reproduction in women.  What is not often appreciated is that estrogen levels, though lower than those in women, are also essential in men.  However, midlife changes in men result in excess estrogen production beyond its minimal essential level.
    Like perimenopausal women, men experience a tendency to gain weight in midlife.  Rising estrogen production can result, since fat cells contain the aromatase enzyme that converts testosterone into estrogen.  Unmetabolized estrogen creates a vicious cycle resulting in further estrogen production.  This occurs because fat is one source of more active aromatase enzymes, causing further estrogen production and continuing weight gain.(27)  An open label study of DIM in overweight men and women showed it promoted more efficient weight loss and more active fat metabolism.
    In this regard, DIM is similar to green tea extract (28 ) and spices like cayenne pepper.(29)  DiindolyImethane may have a role in helping to intervene with excess estrogen production associated with obesity and male aging.  Besides weight gain, another aspect of early aging in men is prostate gland enlargement.
    It has been clearly established that estrogen accumulates in aging prostate glands at the same time enlargement occurs.(30)  This process is linked to difficulty with urination and frequent urination at night.  The role of estrogen is still being established in this process, but research using estrogen binding substances shows lowering estrogen levels improves the symptoms of nighttime urination.(31)  Use of absorbable DIM by men with these same symptoms has proven beneficial.

  • Posted by a hidden member.
    Log in to view his profile

    Jul 22, 2017 11:33 PM GMT
    Estrogens in Men: Another Layer of Complexity of Estradiol Metabolism in Pulmonary Hypertension

    In this issue of the Journal, Ventetuolo and colleagues (pp.–1175) report that in men, elevated levels of estradiol and lower levels of dehydroepiandrosterone sulfate (DHEA-S) are associated with a higher risk for Pulmonary Arterial Hypertension.

    American Journal of Respiratory and Critical Care Medicine
  • Posted by a hidden member.
    Log in to view his profile

    Jul 22, 2017 11:37 PM GMT
    Optimum Range for Estradiol for me is 20-30, but my score is 34.
    My Estradiol is elevated.
    My DHEA-Sulfate is normal and is not on the low side of normal.