COMPOUND KILLS ENERGY GENERATING SYSTEM OF CANCER

  • mwolverine

    Posts: 5726

    Jan 10, 2018 4:56 AM GMT
    COMPOUND KILLS ENERGY GENERATING SYSTEM OF CANCER

    An Israeli researcher devised a synthetic compound to disable the enzymes that allow cancer cells to metastasize.

    When cancer cells leave the primary tumor and spread to other organs, they reprogram their energy-generating system in order to survive in harsh conditions with a shortage of nutrients like glucose.

    Prof. Uri Nir of Bar-Ilan University identified an enzyme called FerT in the energy-generating mitochondria of metastatic cancer cells – an enzyme normally only found in sperm cells (which need to function outside the body they came from). When he targeted FerT in lab mice, the malignant cells soon died.

    Using advanced chemical and robotic approaches, Nir's lab team developed a synthetic compound, E260, which can be administered orally or by injection, causing a complete collapse of the entire mitochondria "power station."

    "We have treated mice with metastatic cancer and this compound completely cured them with no adverse or toxic affect that we can see," reported Nir, adding that normal cells were not affected.

    Phase 1 clinical trials are planned over the next 18 months.

    A novel Fer/FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells
    https://www.nature.com/articles/s41467-017-00832-w
  • mwolverine

    Posts: 5726

    Jan 10, 2018 4:58 AM GMT
    Maybe this century we will beat cancer.
  • MuchoMasQueMu...

    Posts: 1480

    Jan 10, 2018 2:08 PM GMT
    That definitely sounds promising.

    I hope to hear more about it and that it doesn't fade away like so many other promising stories about curbing diseases.