Mycro saidGay or straight. I'll be with my coworkers. They're all good friends and open to gay bars, but I don't care. I'd prefer within walking distance so we don't have to take a bar. I like good beer so I'd like a place that serves more than bud and yuengling.
Definitely want a bar and not a dance club. And I usually like a mixed crowd.
There are lots of places like that Downtown (especially on/near the 16th Street Mall). Or, you might want to try the "LoDo" area North-East of downtown.
You can take the free mall shuttle to the Rock Bottom Brewery or Paramount Cafe.
LoDo has many micro-brewerys, restaurants and bars; take the free mall shuttle to the end, then walk several blocks east. Double Daughter is gay owned, but a mostly straight crowd. Closer to the ball-park, there is also The Wyncoop, Breckenridge Brewery, Flying Dog Brewery, Lodo's Bar & Grill, Fado Irish Pub, Giggling Grizzly.
I haven't hung out in downtown in a while (parking is a bitch), so I'm not familiar with the newer establishments. but I'm sure the front desk can recommend something.
As far as gay establishments, you'd probably want JRs or Hamburger Marys. They are across the street from each other, but they're about 12 blocks from your hotel.