Obestatin: Cure for Obesity?

  • Posted by a hidden member.
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    Nov 10, 2007 6:10 PM GMT
    Obestatin is a hormone that is produced in the cells lining the stomach and small intestine of several mammals including humans; it drastically reduces appetite in mice and is expected to do the same in humans.

  • DiverScience

    Posts: 1426

    Nov 11, 2007 3:43 AM GMT
    COuld be interesting, could be nothing.

    It's related to Ghrelin which turned out to be nothing impressive in humans, but there have been some interesting correlations between obesity and lowered levels of obestatin.

    Unfortunately, when it comes to metabolism, lab mice rarely model wild-type human responses very well. Ghrelin, leptin, and others are good examples of beautiful effects in mice that simply aren't reproduced in humans.

    Also unfortunately, it's a hormone, which means it likely interacts with multiple targets. So who knows what side effects it might have.

    All that said, I'm crossing my fingers that it does turn out to be something cool.
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    Nov 11, 2007 2:48 PM GMT
    I agree with the worry of multiple effects. Ghrelin affects learning too. So who wants to mess with that.