I suffer severe cognitive and occupational impairment (but ADD symptoms are only a component of my total pathology, AXIS 1-5) when I don't take amphetamines. But I won't take them. I was able to go to school and keep my house clean. But I couldn't stand the daily come down after years of taking it (since I was years old), dosage escalation, the pills irritated my stomach, made me really obsessive, they completely burned me out over time. They fix one thing but make several problems worse. I said no more about 3 years ago and I never felt healthier, but my entire life fell apart.
I always have dirty dishes in piles. I wash one dish at time as I need them. Forget about trying to get me to pay attention to you when you speak to me. My laundry strewn all over the room in a mixture of cleans and dirties. My socks never match. I don't really wash my clothes, so much as I air them out and beat the lint and cat hair off of them, a spritz of Hypnose and I'm on my way. I'm usually in need of a shave. I can hyperfocus on some things like fitness and art, but other than that I can't finish anything, not even my art projects.
Provigil and Stratterra were absolute failures. I'm taking Namenda (a novel drug I take for off-label purposes, and alzheimers is a cognitive disorder) now with some marginal success. I am definitely less fidgety and my mood is dramatically better. I thought that since amphetamines were dopaminergic drugs that I should ask my doctor about other dopaminergic drugs like those used for Parkinsons disease. I was on selegeline for a year with marginal improvement in occupational functioning though I was unable to function in school. My diet was never better but the restrictions on numerous other drugs with MAOIs, and its failure to control my mood and anxiety symptoms let to its cessation. I was on amantadine for about 3 weeks and I noticed marked improvement but I was allergic to it. I have been taking ropinirole (requip) for awhile, it helps me sleep better for some reason, though I don't have or believe in restless legs syndrome. It helps with the anhedonic depression a bit. I asked my doctor about COMT (catechol O-methyl tranferase) inhibitors like entacapone. I am wondering if a COMTI coupled with a dopamine agonist might have a similar effect to the amphetamines. Amphetamine functions as an agonist and reuptake inhibitor of dopamine. I also take guanfacine and venlafaxine which both have alpha adrenergic activity which is shared by the L-ampetamine components of the adderall blend. but it still lacks that final PUSH into motion. Cerebral blood perfusion, and excitatory neurotransmission in my dorsolateral prefrontal cortices just won't initiate. I have no occupational salience.
I now take a caffeine tablet with my first daily 24 ounce guava Rockstar. It's almost enough to keep me from fidgeting and improves my working memory. I also have a minimum level of extreme physical activity that must be met if I am going to effectively function. I have this restlessness or akathisia in my bones and tendons and temperament that keeps me from resting or focusing on anything unless I burn myself out. Exercise is absolutely essential. I can't seem to break 160 lbs. I just changed my fitness goal towards endurance.