UCLA: Stem Cells Kill HIV

  • metta

    Posts: 39133

    Dec 08, 2009 5:02 AM GMT
    UCLA: Stem Cells Kill HIV

    http://www.advocate.com/News/Daily_News/2009/12/07/UCLA_Stem_Cells_Kill_HIV/
  • lostlogic

    Posts: 223

    Dec 08, 2009 5:12 AM GMT
    I'm too lazy to do the research but maybe somebody here can enlighten me, is stem cell research going on in other countries?
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    Dec 08, 2009 5:59 AM GMT
    This is going to be terrible pessimistic, I know, but it's so hard to get excited about these things anymore. We all have seen how many times something has been touted as a revolution in HIV treatment/cure/vaccination only to see it crash and burn in actual testing. Especially with stem cell research, which is still so in its infancy, it's just as possible as not that this possible new avenue won't really create the results that are hoped for.
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    Dec 08, 2009 6:11 AM GMT

    Will I come to harm if I mention prevention? Not sure why I would. It's sorta irrelevant here. Ok, bye.

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    Dec 08, 2009 6:13 AM GMT
    QuiltyQueer said
    Will I come to harm if I mention prevention? Not sure why I would. It's sorta irrelevant here. Ok, bye.



    Prevention isn't going to cure the millions of people who already have HIV. These articles give hope to a lot of good people.

    With regards to the research itself, I just hope some of these breakthrough concepts materialize. It seems pretty obvious that eventually a cure will be found. The question is just how long it will take.
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    Dec 08, 2009 6:36 AM GMT
    You changed your screen name. icon_sad.gif
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    Dec 08, 2009 6:51 AM GMT

    Just for an hour or so, all of the supers are doing it around here.
  • handsoffire

    Posts: 178

    Dec 08, 2009 8:05 AM GMT
    Sweet, no not just a flash in the pan.

    Yes it's going on in other countries.
    Japan ad France are the current leaders.

    There's a number of ways that this can work.

    I'll find the links for the research, try to post them tomorrow.
  • metta

    Posts: 39133

    Dec 08, 2009 8:25 AM GMT

    http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008208;jsessionid=8CD1A6487DD9B95FF4C9E3E236AE5EE1


    http://alturl.com/gi92
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    Dec 08, 2009 8:48 AM GMT
    Reading that article, this is HUGE news.

    They're basically creating an immune system that recognizes cells infected with HIV and takes them out before the virus can spread, and also recognizes the virus and kills it... at least that's my understanding.

    Anyone with a larger science background want to translate?
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    Dec 08, 2009 1:27 PM GMT
    Oh boy, stem cell research AND HIV, in one sentence? The conservative redneck Christians would definitely have a field day with that.
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    Dec 08, 2009 1:46 PM GMT
    luvjunkie saidOh boy, stem cell research AND HIV, in one sentence? The conservative redneck Christians would definitely have a field day with that.


    I know... why don't they see that this is a solution?
  • Mikeylikesit

    Posts: 1021

    Dec 08, 2009 2:16 PM GMT
    They dont want a solution....Pharmaceutical companies make why too much $$$$$$ off of meds so they dont want a cure.

    icon_evil.gif
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    Dec 08, 2009 2:48 PM GMT
    Mikeylikesit saidThey dont want a solution....Pharmaceutical companies make why too much $$$$$$ off of meds so they dont want a cure.

    icon_evil.gif


    I agree -they are all in this money making together, but wont they eventually stop making large profits once national health care happens and they will not be allowed to turn you away for a pre-existing condition. I'm sure the ins cos will make drug makers drive down costs.
  • zakariahzol

    Posts: 2241

    Dec 08, 2009 2:53 PM GMT
    For real. I have heard so many thing from AZT to Cocktail and all kind of stuff. But the AIDS virus are smart to hide , mutate and we back to square one.
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    Dec 08, 2009 3:16 PM GMT
    This is exciting news but as others have mentioned, it needs to be a cautious optimism.
    I work in clinical research and have worked on a couple of HIV clinical trials. Unfortunately, many trials are touted early on as being the ones that will kill/cure/stop HIV, only to be relegated to being a 'flash in the pan'. HIV is very smart. Of course it would be awesome if this concept of HIV killing stem cells pans out but I can promise that this initial 'victory' came under the auspices of the most strict and controlled environments. The failed vaccine/drug trials failed once put into real world situations unfortunately.
    Let's remain cautiously optimistic.
    Remember guys: unless you are in a long term, monogamous relationship, wrap it up!
  • jarhead5536

    Posts: 1348

    Dec 08, 2009 3:32 PM GMT
    GuiltyGear said
    Will I come to harm if I mention prevention? Not sure why I would. It's sorta irrelevant here. Ok, bye.



    Prevention efforts continue, indeed have been the primary focus of decades of research. There have been scant moves in the direction of a cure thus far. I'm going to stop talking while I'm still being nice to you...
  • pav1

    Posts: 68

    Dec 08, 2009 3:32 PM GMT
    When I was reading the article and got to the part where it said ..."We have demonstrated in this proof-of-principle study that this type of approach can be used to engineer the human immune system...", this basically translates to "in practical theory". Don't get too excited about a cure just yet. Sorry guys.
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    Dec 08, 2009 3:42 PM GMT
    huckleberry saidThis is exciting news but as others have mentioned, it needs to be a cautious optimism.

    I completely agree.
    And I also think that even the small unsuccessful breakthroughs should be celebrated because the research is being done. Regardless of the strong hold the pharmaceutical companies have on proliferating the disease, regardless of what you think about "prevention", the disease is out there it will continue to spread till there is a cure.
    The small victories remind us what it is like to hold out hope and to not give up. We can not allow those who have died to have died in vain, this might not be the cure but we can't stop believing that one will come.
    "There is no defeat till you quit trying"

    ...just my opinion.
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    Dec 08, 2009 3:43 PM GMT
    onstagebuffnaked said
    Mikeylikesit saidThey dont want a solution....Pharmaceutical companies make why too much $$$$$$ off of meds so they dont want a cure.

    icon_evil.gif


    I agree -they are all in this money making together, but wont they eventually stop making large profits once national health care happens and they will not be allowed to turn you away for a pre-existing condition. I'm sure the ins cos will make drug makers drive down costs.


    I'm also not sure this is entirely true. Let's do a bit of a revenue analysis here.

    There are approximately 1,200,000 people in America currently receiving HIV/AIDS treatment, according to my calculations based on the fact sheet on this page about HIV/AIDS treatment and Medicaid. This page lists the various costs of 24 HIV/AIDS treatments. If you take these and average the costs it comes out to $627 a month. Now, that brings us to annual sales for HIV/AIDS medications to $9,028,800,000 a year.

    Now, let's consider what a vaccine might bring in. Let's take the example of Gardasil, the recently approved HPV vaccine, as a likely comparison of what the cost would be. Over the course of the shots that must be taken, Gardasil costs about $500 for the full vaccine. Considering the extent of HIV/AIDS it is likely that a vaccine would be given to every single person, just as measles shots are. The current population of the US is about 308,000,000. If all were given the vaccine, in one year that would give whatever company came out with it $154,000,000,000 in revenues. There are also about 4 million people born in the US every year, so that's an additional $2,000,000,000 in revenue a year. At that rate, it would take a company 17 years of treatment sales just to reach the original revenue from vaccinating everyone, not including that $2bil a year from newborns.

    And remember, no one company is taking in the entirety of that $9bil revenue, whereas if one company came up with a vaccine or a drug that would cure people (which would mean even more revenue) they would be filthy rich. There is a massive incentive, in fact, for them to find a vaccine for HIV because every one of the companies has to assume that no other company during that 17 years is going to come up with a cure either and thus screw all the other companies.

    So I'm not entirely convinced that this is just some massive conspiracy to treat not cure, because it involves an awful lot of incredibly short term thinking on the parts of companies. This doesn't, of course, take into account patent issues and the effects on drug and vaccine prices, but treatments are just as susceptible to that effect as are vaccines.
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    Dec 08, 2009 4:37 PM GMT
    GwgTrunks saidReading that article, this is HUGE news.

    They're basically creating an immune system that recognizes cells infected with HIV and takes them out before the virus can spread, and also recognizes the virus and kills it... at least that's my understanding.

    Anyone with a larger science background want to translate?


    In simple terms yes. It's kinda like providing reinforcements. The implication is not only a cure for HIV however. But also virtually any infections that the immune system has trouble recognizing.

    One stumbling block however is that, immune systems are very specific to a person. It's very important that the introduced 'reinforcements' are recognized as friendly by the body's immune system, or else it will become a further battlefield that may weaken the immune system even more (which may for instance turn HIV into fullblown AIDS faster).

    Especially since the cells involved, the CD8 "killer" T-Cells don't actually kill the virus. T-cells instead kill infected cells which means that viruses can't anymore replicate. If engineered T-cells are rejected by the original T-cells and/or vice versa, they could mutually find each other hostile and start obliterating each other.

    The amount of genetic matching required would mean that it would be available (at least at first) to only a very few people (kinda like organ transplants). Cord blood that is a genetic match required to get the adult stem cells is also not exactly abundant either (unless you were lucky and your parents saved your umbilical stem cells when you were born).

    Unless of course, like in leukemia patients, it's an autograft. But the process of obtaining hematopoietic stem cells is also not easy and is extremely painful.

    There are other researches that use stem cells in other ways as well. One of which is to take some of the stem cells from a patient and engineer it so that the mature T-cells formed from it would not have the receptor through which the virus injects its own genes. A similar research but more focused on defensive rather than offensive like this one.
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    Jun 08, 2014 10:59 AM GMT
    So what happened?
    This news was 2009 anyone know why nothing happened?
  • Posted by a hidden member.
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    Jun 08, 2014 11:07 AM GMT
    Most recent article I could find:
    http://www.sciencedaily.com/releases/2014/01/140112204708.htm
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    Jun 08, 2014 12:05 PM GMT
    As someone who works as a health practitioner, I can honestly deduce that all this research is just that 'research' scientists spend a lot of government funds doing "research" and It's all in infancy stages, same goes for hypertension, diabetes and cancer (scientists have been "researching" these conditions since the beginning of time) HIV is just a chronic conditon that is manageable & the other best alternative is either prevention or abstinence . Stem cell is just a little too far fetched .