Atripla side effects.

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    Apr 06, 2010 3:15 PM GMT
    I was very fortunate to have maintained a very low viral load and good cd4 for the 11 years without treatment. However, the last year both those counts have both been migrating in the wrong directions and my doctors decided it was time to start meds.

    This is the morning of day 8 on Atripla. I have been taking it near bedtime.

    The first night with Atripla I had some of the usual side effects. Within 3 hours I felt drunk, loopy and slightly disoriented. I had odd, but not disturbing dreams and a bit of a hangover most of the next day. From what I have read up on, not entirely unusual for Sustiva, a component of Atripla.
    Over the next few evenings the feelings of drunkenness gradually subsided as did the odd dreams. I would wake up to use the bathroom and have some difficulty getting back to sleep and have a feeling of general disorientation and unease throughout the day. These symptoms had completely disappeared by day five.

    Now for the fun stuff.

    Last night the dreams were back. I think I ate too close to med time. I was reading that the Sustiva effects can be exacerbated by fatty food. Broccoli cheddar soup and chocolate Easter eggs anyone? When I woke up to use the bathroom in the middle of the night I felt a little itchy. This morning I have a raised rash on my back, shoulders, upper arms and face.
    I put in a call to my doctor’s NP and started reading up on TheBody.com and aidsmeds.com, etc, and concluded that there is little or no need to panic unless I start having acute respiratory involvement. While waiting for the NP to call back, I’ve followed the advice given by the various web sites and taken a Benadryl.

    I am not looking for medical advice on this issue. I have doctors and a very experienced NP for that. What I am interested in are any stories my fellow poz realjockers have concerning Atripla side effects, specifically the Sustiva component.

    Thanks!
    -r
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    Apr 06, 2010 7:36 PM GMT
    Thank you to all those that have sent helpful and supportive e-mails. I do realize that many people while not necessarily closeted about their status and treatment experience, do not exactly live out loud about it either. I greatly appreciate those who have contacted me in private. icon_smile.gif

    -r

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    Apr 08, 2010 3:50 PM GMT
    Unfortunately, Atripla is one of the most widely used medication because of its ease for adherence and one time per day regiment. However the medication does cause vivid dreams at least in the beginning. You do have the right idea about eating before bedtime. Try reading something inspirational or enlightening. Be sure to communicate with your Health care providers about your concerns. There are other medications available but the side effects are different for all.
  • camofchris

    Posts: 73

    Apr 09, 2010 10:52 PM GMT
    I had similar experiences to you while on Atripla in that I had the vivid (interesting) dreams, inability to fall back to sleep in the middle of the night, and aggravated skin issues. For me, the worst was an inability to focus during the waking hours. In my mind, I had 30 things to do, all high priority, but felt the need to try and tackle them all at once. I also noticed significant mood highs and lows (unusual, since I'm generally grounded, up-beat guy).

    I love Atripla for its one-a-day, but opted to moved to a more complicated treatment due to the last item; it got in the way of my profession.

    Cam
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    Apr 21, 2010 9:02 AM GMT
    I've not taken this one yet, but I'm paying close attention to your experiences.

    Do you find that it effects your workouts? I'd hate to feel loopy or dizzy with a 50 pound weight hovering above my head.
  • camofchris

    Posts: 73

    Apr 21, 2010 11:55 AM GMT
    Actually, working out seemed to help the mind focus and rid itself of the loopiness, if that at all makes sense. I also noticed, during the waking hours, most noticable side effects went away.

    The effects of the drug an hour or two after taken always persisted.

    Cam.
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    Apr 21, 2010 12:24 PM GMT
    The only meds I have been on since 2006 are Kaletra and Truvada, and so far, no problems at all, Viral load is undetectable and Tcells around 430. I have had some minor issues with diarrhea from the meds, but that's not too bad. I know, sexy huh icon_smile.gif
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    Apr 27, 2010 4:47 AM GMT
    To answer the question what is HIV AIDS, we have to start early in the epidemic. In 1985, scientists discovered the human immunodeficiency virus (HIV) and with it the question what is aids was answered. 1Y0-220 HIV is a virus that is transmitted from person to person through the exchange of body fluids such as blood, semen, breast milk and vaginal secretions. 1Y0-222 Sexual contact is the most common way to spread HIV AIDS, 1Y0-223 but it can also be transmitted by sharing needles when injecting drugs, or during childbirth and breastfeeding. As HIV AIDS reproduces, it damages the body's immune 1Y0-251 system and the body becomes susceptible to illness and infection. There is no known cure for HIV infection.
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    Apr 27, 2010 5:03 AM GMT
    smith67 saidTo answer the question what is HIV AIDS, we have to start early in the epidemic. In 1985, scientists discovered the human immunodeficiency virus (HIV) and with it the question what is aids was answered. 1Y0-220 HIV is a virus that is transmitted from person to person through the exchange of body fluids such as blood, semen, breast milk and vaginal secretions. 1Y0-222 Sexual contact is the most common way to spread HIV AIDS, 1Y0-223 but it can also be transmitted by sharing needles when injecting drugs, or during childbirth and breastfeeding. As HIV AIDS reproduces, it damages the body's immune 1Y0-251 system and the body becomes susceptible to illness and infection. There is no known cure for HIV infection.


    What does this have to do with the OPs question?
  • Posted by a hidden member.
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    Apr 27, 2010 6:17 PM GMT
    Can't spell ATRIPLA without "trip"

    While I'm not on atripla, sustiva has been a component of my regime for over 4 years and I still have frequent bizarre dreams and occasionally trouble getting back to sleep after waking up in the night.

    I had trouble focusing or concentrating then severe anxiety, which peaked about 19-20 months ago to be almost debilitating. welbutrin took care of that. I'm going to try to taper off welbutrin in about 6 weeks from now and see if I can remain sane without it while still enjoying excellent viral suppression and vivid lucid dreams.
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    Apr 30, 2010 6:47 AM GMT
    I have been on Atripila for 4 years. Most side effects have gone away, but if I wake up and try to get moving before I get a full eight hours of sleep, I still feel pretty "drunk". But, besides that, everything is good. My hats off to all who went before and those who are still testing all the meds that are on the market now. I can't imagine some of the side effects they have gone through. Compared to "regular" meds like Vicadin, this is a breeze.
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    May 01, 2010 9:34 PM GMT
    when my partner started treatment, He had the weird dreams, skin rash, feelling drunk, and out of it. The skin rash lasted about a week, the dreams and feeling drunk last a few months. He has been on the same treatment plan for 6 years now.
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    May 06, 2010 6:39 AM GMT
    I am dating someone who is on Atripla and one of the side effects is his almost revulsion-like feelings at starting sex. Thanks for explaining about the little side effects of starting initial treatment with Atripla. I'm a commercial pilot so it's not the intensity of my job that concers me with the potential of side effects .


    How I Made My Girlfriend Happy - Click Here
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    May 06, 2010 7:20 AM GMT
    Update: A day after my last post I developed an even worse rash, then hives and had a high fever for almost a week even after discontinuing. The rash progressed to the point where the skin began peeling off my face and around my eyes and other more delicate areas down south. The whites of my eyes turned red and began to swell up around my corneas. The skin on my ears actually began to crack a weep serum. It's been almost a month now and my skin is still flaking off in areas.

    The docs and the specialty pharmacist said that it was a previosuly unheard of reaction. Not so much the rash, but the extreme severity of it. Apparently my body has very strong opinions on Sustiva and isn't shy about sharing them with me.icon_lol.gif

    I started Isentress plus Truvada (Truvada contains the other two components of Atripla, Emtriva and Viread) a little over a week ago. Other than some insomnia that may or may not be related to it, I feel fantastic. If I last a full month without any more crazy reactions, I should be in the clear.

    This has been an unpleasant adventure. When it gets me down, I just think about all the people before me that had to deal with the original AZT, the high doses of Norvir, the disfiguring effects of Zerit and count myself very very lucky. icon_smile.gif
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    May 08, 2010 2:25 AM GMT
    Wow, it sounds like you had a full blown allergic reaction. I'm glad you came through the side effects ok and that you're tolerating the new regime much better. I've got my fingers crossed that you have smooth sailing for a long time. You're owed it !
  • motney

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    May 14, 2010 2:38 AM GMT
    I have recently been diagnosed and will start my treatment during my next visit to the doctor on June 9th. Besides the HIV I will be battling Hep B too. Sure hope the meds are not too tough on me.

    I have always been in great shape working out the past 10 years. I would say I have been poz for a number of years. Have had vivid dreams for about three years nows. Not sure what the viral load of the HIV is until the next Dr visit. I do know the Hep viral load is very high.

    Had a MRSA infection 2 months ago and now getting over another one. Beside that I have felt great.

    Will share the story after I begin the fight with meds.
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    May 23, 2010 2:45 PM GMT
    Man, sorry to hear you had such a tough go of it with Apripla! I had a bit of dizziness right out of the box and have the occasional strange dreams (your point about certain types of foods certainly rings true with me). Otherwise, the big A has been a godsend for me.

    Hope that your switch to the new regimen is continuing to go very well!
  • cjgdesignr

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    Jun 04, 2010 10:00 PM GMT
    I've been positive for nine years and was immediately put on sustiva after diagnosis. Then ended up switching to atripla as soon as it came out.

    The trippiness associated from sustiva really created issues with insomnia (still have to take two ambien to sleep every night). I asked my doctor if I could switch to a morning dose, and since then, things are fine. Yes, sometimes I do have some of the "foggy" symptoms, but not as bad as the trippy dreams I used to have. Just be careful it you move it to the morning and do the change gradually... (eg: one day, take it three hours earlier than normal; the next day three hours earlier than the previous, and so forth). I also use this method when I have to travel time zones to keep on schedule if I'm gone for an extended period of time.

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    Aug 06, 2010 1:59 AM GMT
    I started Atripla about 6 months ago from another treatment. The only side-effect I got from the pill is a fucked up digestive system. I was kinda looking forward to the vivid dreams and the loopy feeling but never got it. I was told I would definitely get it. Not a single vivid dream, No rash, no loopy feelings either... So it certainly affects everyone differently.
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    Aug 26, 2010 6:08 PM GMT
    I started Atripla for the first time after 17 years with HIV, last week.
    I could not tolerate it - I woke the next morning after a night of crazy dreams feeling feverish, mega hungover, sick shaky, numb hands and feet, feeling completely off my head with a buzzing sensation throughout my body. It was AWFUL. I carried on for 5 more nights to see if it would go away but it didn't. I literally felt so bad on Atripla that I had to come off it. My doc changed me to etravirine and truvada and am much much better on this. Did anyone else have severe side effects with atripla? And did they pass? and does anyone know the success rate of my new drugs? How long can I expect to take them before resistance kicks in?
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    Aug 26, 2010 6:11 PM GMT
    I know a guy who takes it, he has really disturbing dreams
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    Aug 26, 2010 6:28 PM GMT
    Jboy1968 saidI started Atripla for the first time after 17 years with HIV, last week.
    I could not tolerate it - I woke the next morning after a night of crazy dreams feeling feverish, mega hungover, sick shaky, numb hands and feet, feeling completely off my head with a buzzing sensation throughout my body. It was AWFUL. I carried on for 5 more nights to see if it would go away but it didn't. I literally felt so bad on Atripla that I had to come off it. My doc changed me to etravirine and truvada and am much much better on this. Did anyone else have severe side effects with atripla? And did they pass? and does anyone know the success rate of my new drugs? How long can I expect to take them before resistance kicks in?


    I was on Truvada and Epivir for YEARS before I switched doctors due to a move, and they wanted to switch me to a one pill, once a day. I have always been undetectable... even after YEARS, at least 4 or 5 years on Atripla and Epivir. Come to think about it, I have been on a Viramune based drug since I was first infected almost 15 years ago. And I have never had to change or developed resistance to Viramune, or any drug for that matter. As long as you don't take any vacations, you probably won't develop resistance.
  • Geoedward

    Posts: 657

    Aug 26, 2010 6:35 PM GMT
    I have been positive for about 28 years. I have been on meds for 18 years.
    You guys are making me really nervous because I have been on the same meds for all of these years. Trizivir and Kalitra. My doctor wants to take me off of them this Friday because after all these years he thinks it is causing me to get kidney stones. I have been getting them once a month for the last year. I also have to take Lipitor and Tricor everyday because the meds
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    Aug 31, 2010 1:24 AM GMT
    Geoedward saidI have been positive for about 28 years. I have been on meds for 18 years.
    You guys are making me really nervous because I have been on the same meds for all of these years. Trizivir and Kalitra. My doctor wants to take me off of them this Friday because after all these years he thinks it is causing me to get kidney stones. I have been getting them once a month for the last year. I also have to take Lipitor and Tricor everyday because the meds
    \

    The newer drugs have very few side effects.

    Kaletra is one of the worst, but it's a good drug otherwise. There are plenty of options of you can't take it.

    I couldn't. After weeks I spent 3 days in a corner crying before someone told me stop taking it. I was fine in a day.
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    Aug 31, 2010 1:26 AM GMT
    NoCityGuy saidAs long as you don't take any vacations, you probably won't develop resistance.


    Studies in prisons where they can watch people take the meds - they can't lie about it - back up that it's very very very rare to develop resistance to anything if you always take it.